Alternative Modes of Liquid Chromatography for Oligonucleotides

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This episode focuses on alternative modes of liquid chromatography (LC) for oligonucleotides as current go-to chromatographic modes may face significant changes in the future.

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      Historically, most products and methods are produced with similar modes of chromatography. For oligonucleotides, reversed-phase ion pair chromatography (IPC) and hydrophilic interaction liquid chromatography (HILIC) are two common modes. Considering the potential of future restrictions, the panel talks about alternative modes of LC for oligonucleotides.

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