Corporate Retrospective 2007: Bruker
We are pleased indeed to have been partnering with LCGC for North America many years in briefing scientists worldwide about our numerous LC–MS product announcements and extensive LC–MS applications news.
We are pleased indeed to have been partnering with LCGC for North America many years in briefing scientists worldwide about our numerous LC–MS product announcements and extensive LC–MS applications news. We find LCGC application notes to be a great tool to inform scientists about the very latest technological advances. LCGC has a well-informed readership that understands the research implications of our novel new LC–MS capabilities. LCGC application notes are an excellent way for us to provide the scientific community with real world data. In addition, we find that our advertisements in LCGC are well received by scientists, often generating requests to visit our worldwide demonstration labs to test out our newest instruments with their most challenging real world samples.
We consider LCGC to be an ideal medium for communicating news on all our MS capabilities.
Two years ago, we introduced the world's first high-capacity ion trap with electron transfer dissociation (ETD) capability. Last year at Pittcon 2006, our newly announced post-translational modification methods further extended our customers' ability to achieve automated, intelligent phosphorylation, and glycosylation characterization. The announcement enabled this important branch of proteomics on our robust, ultra-high sensitivity ion traps, and further established Bruker Daltonics as the leader in PTM research, ETD, and proteomics research by mass spectrometry. LCGC application notes are our vehicle of choice for communicating this kind of scientific advance.
In combination with the exceptional performance of our mass spectrometers in acquisition speed, mass accuracy, speed, and conventional collision induced dissociation, Bruker's advanced ETD technology has been opening the door for many of our customers worldwide to easily access the type and location of various PTMs, both quickly and conveniently. Our customers are finding that ETD fragmentation of large peptides results in a very complete set of c-and z-fragments due to the random fragmentation of all N-Cα bonds. These customers are seeing that the Bruker ETD takes full advantage of the excellent mass accuracy of the ion trap, making it the ideal tool for de novo sequencing applications. We'll publish more application notes on these kinds of topics in all the European, North American, and Asia-Pacific LCGC editions on a regular basis.
Clive Seymour
Clive Seymour
Vice President for Asia-Pacific
Bruker Daltonics
Bremen, Germany
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
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The Intricacies of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
