Tosoh Corporation, the parent company of Tosoh Bioscience, was established in Japan in 1935 as a domestic producer of caustic soda and soda ash.
Tosoh Corporation, the parent company of Tosoh Bioscience, was established in Japan in 1935 as a domestic producer of caustic soda and soda ash. Today, Tosoh is a multinational corporation that supplies inorganic chemicals, petrochemicals and specialty materials.
Not satisfied with the performance of gel permeation chromatography columns available in the late 1960s, Tosoh developed its own GPC columns for the analysis of its polymer products. Responding to numerous requests, Tosoh started to share the S-type columns with other polymer manufacturers in 1971, the year that marks the beginning of Tosoh's liquid chromatography business and the birth of the TSK-GEL brand. Following this milestone, Tosoh completed its first generation product portfolio by the end of 1970s. Included were silica-and polymer-based TSK-GEL columns for all common modes and HPLC instrumentation. In the 1980s Tosoh launched the Toyopearl resins for the purification of biopharmaceutical drugs in commercial manufacturing processes.
Tosoh Bioscience was established in 1987 as TosoHaas, a joint venture between Tosoh and the Rohm and Haas Company, to better serve markets outside of Japan. In 2000, Tosoh Bioscience became a wholly owned subsidiary of Tosoh Corporation with sales, marketing, and technical service offices in the United States and Germany.
Today, TSK-GEL columns for high performance size-exclusion chromatography are used by researchers and quality control chemists who depend on these best-in-class columns to analyze proteins and all types of industrial polymers. It is less well known that Tosoh stood at the forefront of the current trend towards ultra-high performance with the groundbreaking introductions of 2.2-μm silica and 2.5-μm non-porous resin particles in the mid 1990s. Tosoh was also an early leader in the search for better solutions for the retention of highly polar compounds.
In recent years, Tosoh has introduced new lines of reversed phase and HILIC columns, which further exemplify Tosoh's ability to provide timely and innovative solutions for today's most challenging separation problems. Quality products, coupled with unwavering customer support, remain the focus for all employees in the Tosoh Bioscience group.
By combining expertise and a portfolio of over 500 specialty products, Tosoh continues to provide innovative solutions in basic biological research, drug discovery, medicinal chemistry, agriculture, manufacturing, and other industrial applications around the globe.
Congratulations to LCGC on their 25th anniversary.
Tosoh Bioscience
Measuring Procyanidin Concentration in Wines Using UHPLC
January 24th 2025Researchers from the University of Bordeaux (Villenave d'Ornon, France) report the development and validation of a rapid and quantitative analytical method measuring crown procyanidin concentration in red and white wines using ultra-high performance liquid chromatography (UHPLC) coupled with a ultra-high performance liquid chromatography (Q-TOF) mass spectrometer.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Testing Solutions for Metals and PFAS in Water
January 22nd 2025When it comes to water analysis, it can be challenging for labs to keep up with ever-changing testing regulations while also executing time-efficient, accurate, and risk-mitigating workflows. To ensure the safety of our water, there are a host of national and international regulators such as the US Environmental Protection Agency (EPA), World Health Organization (WHO), and the European Union (EU) that demand stringent testing methods for drinking water and wastewater. Those methods often call for fast implementation and lengthy processes, as well as high sensitivity and reliable instrumentation. This paper explains how your ICP-MS, ICP-OES, and LC-MS-MS workflows can be optimized for compliance with the latest requirements for water testing set by regulations like US EPA methods 200.8, 6010, 6020, and 537.1, along with ISO 17294-2. It will discuss the challenges faced by regulatory labs to meet requirements and present field-proven tips and tricks for simplified implementation and maximized uptime.