Robustness and Reproducibility: Is There a Competency Crisis?

EP: 1.Introducing the Panel: The State of The Art in Oligonucleotide Analysis

EP: 2.Challenges in Analyzing Antisense Oligonucleotides (ASOs)

EP: 3.Chemistries and Products Available for ASOs

EP: 4.Discussing Analytical Strategies and 2DLC

EP: 5.The Regulatory Stance on Oligonucleotide Enantiomers

EP: 6.Future Perspectives and Fit-For-Purpose Separation Power

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EP: 7.Robustness and Reproducibility: Is There a Competency Crisis?

EP: 8.On-Column Structural Formations

EP: 9.PFAS and Fluorinated Compounds: Considering Potential Future Restrictions

EP: 10.Alternative Modes of Liquid Chromatography for Oligonucleotides

In routine methods, there is an arguable lack of reproducibility in the industry. The panel shares their thoughts on the sources of this problem, as well as whether or not reproducibility is necessary in developing robust methods.