Challenges in Analyzing Antisense Oligonucleotides (ASOs)
The main focus of this Peer Exchange is on the state of the art for antisense oligonucleotides (ASOs) in particular. The panel shares their perspectives on the most pressing analytical challenges the industry currently faces regarding these oligonucleotides.
The panel discusses current challenges in oligonucleotide analysis, particularly in the case of ASOs. Claus Rentel of Ionis Pharmaceuticals mentions that often, working with ASOs, the impurity profile is a main concern. Arnaud Delobel adds that mass spectrometry (MS) is required to analyze oligonucleotides fully. From an academic perspective, Mark Dickman suggests that the diversity of new chemical modalities and modifications present additional complexities.
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