Challenges in Analyzing Antisense Oligonucleotides (ASOs)
The main focus of this Peer Exchange is on the state of the art for antisense oligonucleotides (ASOs) in particular. The panel shares their perspectives on the most pressing analytical challenges the industry currently faces regarding these oligonucleotides.
EP: 1.Introducing the Panel: The State of The Art in Oligonucleotide Analysis
Now Viewing
EP: 2.Challenges in Analyzing Antisense Oligonucleotides (ASOs)
EP: 3.Chemistries and Products Available for ASOs
EP: 4.Discussing Analytical Strategies and 2DLC
EP: 5.The Regulatory Stance on Oligonucleotide Enantiomers
EP: 6.Future Perspectives and Fit-For-Purpose Separation Power
EP: 7.Robustness and Reproducibility: Is There a Competency Crisis?
EP: 8.On-Column Structural Formations
EP: 9.PFAS and Fluorinated Compounds: Considering Potential Future Restrictions
EP: 10.Alternative Modes of Liquid Chromatography for Oligonucleotides
The panel discusses current challenges in oligonucleotide analysis, particularly in the case of ASOs. Claus Rentel of Ionis Pharmaceuticals mentions that often, working with ASOs, the impurity profile is a main concern. Arnaud Delobel adds that mass spectrometry (MS) is required to analyze oligonucleotides fully. From an academic perspective, Mark Dickman suggests that the diversity of new chemical modalities and modifications present additional complexities.
Recent Videos
Related Content
