Chemistries and Products Available for ASOs

There is a broad range of chemistries available for the analysis of oligonucleotides, and the panel narrows in on stationary phases and column materials relevant to ASOs.

EP: 1.Introducing the Panel: The State of The Art in Oligonucleotide Analysis

EP: 2.Challenges in Analyzing Antisense Oligonucleotides (ASOs)

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EP: 3.Chemistries and Products Available for ASOs

EP: 4.Discussing Analytical Strategies and 2DLC

EP: 5.The Regulatory Stance on Oligonucleotide Enantiomers

EP: 6.Future Perspectives and Fit-For-Purpose Separation Power

EP: 7.Robustness and Reproducibility: Is There a Competency Crisis?

EP: 8.On-Column Structural Formations

EP: 9.PFAS and Fluorinated Compounds: Considering Potential Future Restrictions

EP: 10.Alternative Modes of Liquid Chromatography for Oligonucleotides

The panel covers the current chemistries and products available for oligonucleotides, ASOs in particular. They agree that while there is room to innovate and improve, the future of oligo separation looks promising.

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