Discussing Analytical Strategies and 2DLC
This episode covers strategies in place for the analysis of impure mixtures with a larger range of retention factors while still maintaining separation power.
EP: 1.Introducing the Panel: The State of The Art in Oligonucleotide Analysis
EP: 2.Challenges in Analyzing Antisense Oligonucleotides (ASOs)
EP: 3.Chemistries and Products Available for ASOs
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EP: 4.Discussing Analytical Strategies and 2DLC
EP: 5.The Regulatory Stance on Oligonucleotide Enantiomers
EP: 6.Future Perspectives and Fit-For-Purpose Separation Power
EP: 7.Robustness and Reproducibility: Is There a Competency Crisis?
EP: 8.On-Column Structural Formations
EP: 9.PFAS and Fluorinated Compounds: Considering Potential Future Restrictions
EP: 10.Alternative Modes of Liquid Chromatography for Oligonucleotides
Discussing analytical strategies, Arnaud Delobel and Claus Rentel consider mass spectrometry (MS) the best approach, and Mark Dickman covers the potential of 2DLC.
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