Discussing Analytical Strategies and 2DLC

This episode covers strategies in place for the analysis of impure mixtures with a larger range of retention factors while still maintaining separation power.

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EP: 1.Introducing the Panel: The State of The Art in Oligonucleotide Analysis

EP: 2.Challenges in Analyzing Antisense Oligonucleotides (ASOs)

EP: 3.Chemistries and Products Available for ASOs

Now Viewing

EP: 4.Discussing Analytical Strategies and 2DLC

EP: 5.The Regulatory Stance on Oligonucleotide Enantiomers

EP: 6.Future Perspectives and Fit-For-Purpose Separation Power

EP: 7.Robustness and Reproducibility: Is There a Competency Crisis?

EP: 8.On-Column Structural Formations

EP: 9.PFAS and Fluorinated Compounds: Considering Potential Future Restrictions

EP: 10.Alternative Modes of Liquid Chromatography for Oligonucleotides

Discussing analytical strategies, Arnaud Delobel and Claus Rentel consider mass spectrometry (MS) the best approach, and Mark Dickman covers the potential of 2DLC.

Recent Videos

Alternative Modes of Liquid Chromatography for Oligonucleotides

PFAS and Fluorinated Compounds: Considering Potential Future Restrictions

On-Column Structural Formations

Robustness and Reproducibility: Is There a Competency Crisis?

Future Perspectives and Fit-For-Purpose Separation Power

The Regulatory Stance on Oligonucleotide Enantiomers

Chemistries and Products Available for ASOs

Challenges in Analyzing Antisense Oligonucleotides (ASOs)

Introducing the Panel: The State of The Art in Oligonucleotide Analysis