On-Column Structural Formations

EP: 1.Introducing the Panel: The State of The Art in Oligonucleotide Analysis

EP: 2.Challenges in Analyzing Antisense Oligonucleotides (ASOs)

EP: 3.Chemistries and Products Available for ASOs

EP: 4.Discussing Analytical Strategies and 2DLC

EP: 5.The Regulatory Stance on Oligonucleotide Enantiomers

EP: 6.Future Perspectives and Fit-For-Purpose Separation Power

EP: 7.Robustness and Reproducibility: Is There a Competency Crisis?

Now Viewing

EP: 8.On-Column Structural Formations

EP: 9.PFAS and Fluorinated Compounds: Considering Potential Future Restrictions

EP: 10.Alternative Modes of Liquid Chromatography for Oligonucleotides

Under certain chromatographic conditions, spontaneous base pairing can occur. The panel discusses their experience with on-column structural formations and modifications.