Corporate Retrospective 2007: Regis
Regis Technologies, Inc. has a long-standing history of collaborating with leading scientists in the development of innovative chromatographic technology.
Regis Technologies, Inc. has a long-standing history of collaborating with leading scientists in the development of innovative chromatographic technology. Our entry into the chromatography business began in 1966 with a reagent kit that made it possible to analyze natural protein amino acids by gas chromatography (GC). Developed by Charles Gehrke and David Stalling at the University of Missouri, this derivatization technology enabled the GC analysis of non-volatile biomolecules. The line of derivatization reagents grew with kits for urinary steroids and carbohydrates, and has expanded into a full line of derivatization products.
Regis began to develop HPLC columns and packings after John Perry joined Regis in 1970. With the idea of developing high performance thin-layer chromatography, Perry innovated programmed multiple development and short bed continuous development. Although these developments created significant interest at the time, they were soon dwarfed by the growing interest in HPLC. John brought Regis into the HPLC business with the first reversible HPLC columns.
William Pirkle at the University of Illinois became interested in Regis' efficient HPLC columns and began developing methods for separating enantiomers by HPLC. Working with Pirkle, Regis developed and marketed a line of HPLC columns and packings. These chiral columns continue to offer advantages in efficiency, stability, and the useful advantage of reversing enantiomer elution.
Two more research scientists, this time from Purdue University, came to Regis. Tom Pinkerton's restricted access media (RAM) columns permit the direct injection of serum for drug analyses, while Charles Pidgeon's immobilized artificial membrane (IAM) columns enabled the prediction of drug membrane permeability.
More recently, Regis added supercritical fluid chromatography services to its stable of separation capabilities. This environmentally friendly technique, using liquid CO2 as the primary mobile phase, is being applied at Regis in kilo quantity separations, following the GMP guidelines of the FDA.
Today, Regis Technologies manufactures HPLC columns for conventional and specialty separations. Regis manufactures derivatization reagents for GC and ion pair reagents and buffers for HPLC.
Congratulations to LCGC North America on their 25th Anniversary.
Louis J. Glunz
Louis J. Glunz III
Chairman
Regis Technologies, Inc.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
