September 4th 2024
Stockholm University scientists used liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) to characterize recycled textile products and detect harmful chemicals.
Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles from Haystacks
July 1st 2011Ion mobility–mass spectrometry (IM-MS) is outlined as a separations method, several examples of the utility of IM-MS for complex biological measurements are illustrated, and the implications of this approach for systems biology research are discussed.
Mass Spectrometry Test for Sports Doping
July 15th 2008Researchers at the University of Utah's (Salt Lake City) Sports Medicine Research and Testing Laboratory developed a test for testosterone and epitestosterone in urine that uses liquid chromatography with tandem mass spectrometry detection (LC-MS-MS).
Synthesis and Structural Elucidation of Impurities in Ramipril Tablets
July 1st 2008Ramipril impurities D and E are well-known degradation products of ramipril in the finished dosage form. A significant amount of an additional impurity was detected in ramipril tablets by an isocratic reversed-phase high performance liquid chromatography (HPLC) method on a short column. The structure of this impurity was proposed based on liquid chromatography–mass spectrometry (LC–MS) data using an electron spray ionization source. Structural elucidation using nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy was facilitated by a newly developed preparative isolation method. This impurity was characterized as (2R,3aR,6aR)-1-[(R)-2-[[(R)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (impurity L). Its identification, synthesis and characterization are discussed.
Incipient Technologies: Desorption and Thermal Desorption Techniques
December 1st 2007Nearly a dozen incipient technologies have appeared in recent years. Which will survive? Which will find extensive, robust usage as did electrospray ionization? Which are fated to become footnotes in mass spectrometry practice?
Mass Spectrometry Imaging In Need of Improvement
August 30th 2007Understanding how imaging can advance life science research and what issues need to be addressed to unlock the true potential of mass spectrometry-based imaging raises awareness of new possibilities for researchers. This article explores mass spectrometry imaging, aiming to educate about scientific opportunities to consider and the pitfalls to avoid.