Webinar Date/Time: Thu, Feb 8, 2024 11:00 AM EST
Achieve higher productivity in cell line optimization. Learn how a streamlined middle-down mass spectrometry workflow can improve molecular knowledge in less steps.
Register Free: https://www.biopharminternational.com/bp_w/middle-down-analysis
Event Overview:
In biotherapeutic development, changing cell culture conditions is necessary to enable simpler, faster and more cost-effective drug delivery to patients. These changes, however, can induce cellular stress and adversely impact product quality, creating additional challenges in manufacturing.
Reliable and streamlined workflows to characterize post-translational modifications (PTMs) are necessary to create a comprehensive molecular profile of a biopharmaceutical. Adopting workflows that provide these critical pieces of information with minimal processing steps allows for less labor intensive characterization of PTMs and reduces the risk of introducing artificial PTMs or other undesirable modifications.
Key Learning Objectives:
Who Should Attend:
Speaker:
Hirsh Nanda
Director, Analytical Sciences
J&J Innovative Medicine
Hirsh Nanda is the Director of Analytical Sciences at Johnson & Johnson Innovative Medicines. Hirsh joined J&J in 2015. In his current role, he leads an Analytical Sciences group supporting research and development of biologic therapeutics, including cell line engineering and development. His team performs in-depth mass spectroscopy and biophysical characterization across modalities and next-generation therapies.
Register Free: https://www.biopharminternational.com/bp_w/middle-down-analysis
Silvia Radenkovic on Her Research and Passion for Scientific Collaboration
April 3rd 2025Radenkovic is a PhD candidate at KU Leuven and a member of FeMS. Her research focuses on inborn metabolic disorders (IMD), like congenital disorders of glycosylation (CDG), omics techniques such as tracer metabolomics, and different disease models.
Study Explores Thin-Film Extraction of Biogenic Amines via HPLC-MS/MS
March 27th 2025Scientists from Tabriz University and the University of Tabriz explored cellulose acetate-UiO-66-COOH as an affordable coating sorbent for thin film extraction of biogenic amines from cheese and alcohol-free beverages using HPLC-MS/MS.
Quantifying Microplastics in Meconium Samples Using Pyrolysis–GC-MS
March 26th 2025Using pyrolysis-gas chromatography and mass spectrometry, scientists from Fudan University and the Putuo District Center for Disease Control and Prevention detected and quantified microplastics in newborn stool samples.
Multi-Step Preparative LC–MS Workflow for Peptide Purification
March 21st 2025This article introduces a multi-step preparative purification workflow for synthetic peptides using liquid chromatography–mass spectrometry (LC–MS). The process involves optimizing separation conditions, scaling-up, fractionating, and confirming purity and recovery, using a single LC–MS system. High purity and recovery rates for synthetic peptides such as parathormone (PTH) are achieved. The method allows efficient purification and accurate confirmation of peptide synthesis and is suitable for handling complex preparative purification tasks.