Liquid Chromatography (LC/HPLC)

When considering different ways to improve an established LC method, it helps to start by reviewing some essential concepts.

Robots outperform humans in five areas, and thus can be particularly beneficial for performing sample preparation for HPLC.

A harmonization of all conventional hold-up volume methods was successfully applied to RPLC, HILIC, AEX, and RP-AEX mixed-mode chromatography, regardless of the mobile phase.

Developing a short list of the likely causes of these results can help streamline our troubleshooting experience when sensitivity-related problems occur.

Webinar Date/Time: Thu, Jan 19, 2023 11:00 AM EST

Quantifying the content of coumarin and cinnamaldehyde in cinnamon products

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

Estimating expected peak widths helps us determine when a column and LC system is not performing optimally.

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

TRLC can obtain separations similar to those of reversed-phase LC while using only water as the mobile phase.

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

The values determined by van’t Hoff analysis only have practical significance if we analyze the results obtained with well-planned and systematically varied experiments.

Learning or mastering new skills as an adult can feel daunting. These three tips will help.

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

Webinar Date/Time: Mon, Dec 12, 2022 11:00 AM EST

Webinar Date/Time: Tue, Dec 13, 2022 11:00 AM EST

Webinar Dates/Times: Wednesday, December 14th, 2022 at 10am EST|3pm GMT Wednesday, December 14th, 2022 at 2pm EST|11am PST Thursday, December 15th, 2022 at 12pm JST|11am CST

The Column spoke to Brett Paull from the University of Tasmania in Hobart, Australia, about the development of truly portable LC systems for use in the pharmaceutical industry and in environmental analysis. Why are they necessary, and where can improvements still be made?

I recently read a nice article from The Robot Report (1) that contrasted the performance of robots in industry against those of humans. The takeaways from the report are as follows.

What’s the fastest way to acquire a new chromatographic skill? The answer lies with those who are just beginning to learn.

Knowing the tips and tricks of producing quality LC–MS data for peptide analysis can help streamline troubleshooting when problems occur.

There are various physical and chemical causes of low detection sensitivity. Here, we address some of these causes, and how to troubleshoot them.

The application of porous layer open tubular (PLOT) columns can be expanded beyond light compounds to separations of analytes with heavier boiling points.

This case study of the career path of a separation scientist illustrates the diversified roles of an analytical chemist in nonclinical drug development.

The return of the in-person HPLC Conference was welcomed by the separation science community. There were a lot of developments to share.

The method presented here, which uses a novel needle trap device (NTD) with sol-gel PEG-coated fibers in conjunction with GC, is a simple, inexpensive, and accurate tool for the analysis of trace levels of PCBs in water samples.

What’s the fastest way to acquire a new chromatographic skill? The answer lies with those who are just beginning to learn.

Part 2 of a review of the recent Chromatographic Society (ChromSoc) spring symposium meeting focusing on small molecule analysis.