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For an international conference, highlighting the diversity of research, and the people performing it, is important. Diversity comes in a lot of different flavors: Industrial vs. academic; different cultures, values, needs, and resources; age and gender; among others. Representatives from all different backgrounds and experiences should be given a voice.

Click the title above to open the LCGC North America October 2018 issue in an interactive PDF format.

Click the title above to open the October 2018 issue of Current Trends in Mass Spectrometry in an interactive PDF format.

Click the title above to open the LCGC Europe October 2018 regular issue in an interactive PDF format.

Click the title above to open the LCGC Europe October 2018 Supplement: Advances in Pharmaceutical Analysis in an interactive PDF format.

The past decade has witnessed resurgent interest in coupling GC to atmospheric-pressure chemical ionization (APCI), which is suitable for the high column flows required for using flow modulation. This study assesses the use of GP-APCI with flow modulation for sensitive detection of selected trace organics.

The structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).

This instalment provides an overview of the modern trends and best practices in mobile-phase selection for reversed-phase liquid chromatography (LC). In particular, we focus on selection criteria and rationales for enhancing analytical performance and ease of preparation.

Topics that stood out at HPLC 2018 include advances in large-molecule separations, multidimensional separations, 3D printing, chiral separations, and HILIC. Also, many speakers addressed separation fundamentals, including ways to increase speed, generate higher throughput, and add selectivity.

Many LC users are unclear what happens when we combine two (or more) flow streams in LC systems, and when mixers are needed to blend the fluids. This discussion explains why mixers are needed, and when and how you might consider using something other than the default mixer setting.

Modern trends in LC mobile-phase selection and preparation include using simpler mobile phases, increased use of MS-compatible mobile phases, and eliminating filtration and certain mobile-phase additives. Here, we discuss those and other trends and best practices, as well as the fundamentals behind them.

Molecularly imprinted polymers can replace conventional sorbent materials in sample preparation techniques such as solid-phase extraction (SPE), solid-phase microextraction (SMPE), and matrix solid-phase dispersion (MSPD), offering increased selectivity over the target analytes.

Elena Ibañez is determined to make sample preparation for food analysis not only more environmentally friendly but also more efficient, as she explores approaches that simplify solvent selection, increase solvent selectivity, and lessen the role of chemical solvents.

Proper tuning and calibration of instruments ensure their peak response and an exact mass-to-charge ratio and ion abundance measurement.

What types of mixers are needed with different types of liquid chromatography (LC) pumps? Are different mixers needed for different applications?

The 9th SCM symposia (SCM-9) will take place from 30 January to 1 February 2019, in Amsterdam, The Netherlands.

Researchers from the University of Verona, in Verona, Italy, have investigated the diagnosis of diabetes mellitus in endurance athletes using HPLC.

An introduction from the guest editors of this special supplement from LCGC Europe focusing on recent trends in pharmaceutical analysis.

This study demonstrates a new LEAN approach and method, where 25 solvents can be simultaneously determined based on predetermined relative response factors (RRFs) against an internal standard (decane) with only one injection of sample solution.

Waters and Restek have entered into a co-marketing agreement aimed at food safety laboratories and promoting the use of Waters gas chromatography–mass spectrometry instruments with Restek GC consumables.

Toxicological surveillance of illicit prescription and illegal drug abuse has been carried out using post-mortem data from Clark Country, Nevada, USA, with GC–MS, headspace GC–MS, GC×GC–MS, LC–MS, and ELISA.

Analysis of red lacquerwares from the Japanese Jõmon Period (approximately 14,000 to 500 BC) by Py-GC–MS has revealed the materials and fabrication techniques used in their production.

Shimadzu has been awarded the 2018 NRW.Invest Award by the North Rhine‑Westphalia (NRW) region of Germany.

The functional properties of polymers, such as poly(lactic-co-glycolic acid) (PLGA), relevant to drug delivery and biomedical devices, are governed by the molecular properties of molar mass, composition, conformation, and branching. This article demonstrates how such polymers are fully characterized, quickly and absolutely, using gel permeation chromatography (GPC) with multi-angle light scattering (MALS) and online viscometry.

Approximately 40% of recombinant proteins that are purified use a histidine tag for easy capture. This article covers how to automate the purification of histidine-tagged proteins and how purification conditions can be optimized to an automated four-step purification scheme that uses affinity-, ion exchange-, and size-exclusion columns. Using a multistep purification scheme removes the manual steps that cause loss of precious proteins and take more time, like dialysis, collection, and reinjecting samples. The final purification scheme reduces a 3–4-day process to 11.5 h from start to finish, all while improving reproducibility, yield, and comparable purity.

Click the title above to open The Column September 2018 North American issue, Volume 14, Number 9, in an interactive PDF format.

Click the title above to open The Column September 2018 Europe & Asia issue, Volume 14, Number 9, in an interactive PDF format.