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Current Trends in Mass Spectrometry, July 2018

The use of superficially porous particles (SPPs) for modern high performance liquid chromatography (HPLC) is now very common. Initially, SPPs rose as an alternative to sub-2-µm fully porous particles (FPPs). In recent years, many column manufacturers have developed 2-µm and smaller SPP-based products. This article investigates the practical utility of these smaller SPP designs.

Many manufacturers now offer columns using superficially porous particles that are 2-µm and smaller. When should you use them?

While capillary gas chromatography has been undergoing a renaissance, with new columns, detectors, data systems, and multidimensional separations, the classical inlets have remained the same: We are still injecting liquid samples with syringes into split and splitless inlets, as we have for nearly 50 years. Split and splitless injections present several well-known and some not-so-well known challenges, mostly arising from heating of the inlet, that make sample injection and inlets a major hurdle for gas chromatographers. These challenges and some ideas for mitigating them are discussed and a case is made for renewed exploration of the cool inlets and injection techniques: cool on-column and programmed temperature vaporization.

The 32nd International Symposium on Chromatography (ISC 2018) will be held on 23–27 September 2018 in Cannes-Mandelieu, France.

We discuss the challenges of split and splitless injections, ideas for mitigating them, and the case for renewed exploration of cool inlets and injection techniques.

This is the first of three articles looking at the impact of the new United States Pharmacopeia (USP) chapter on Analytical Instrument Qualification (AIQ) on data integrity in a regulated chromatography labora-tory. In part 1, user specifications for chromatography systems and the relationship between users and sup-pliers will be discussed.

The Chromatographic Society and the Royal Society of Chemistry Analytical Division North East Region has organized a meeting to be held on 22 November 2018 in the Stadium of Light, Sunderland, UK.

To extend the life of your GC columns, follow these best practices.

You need to ensure that your calculations of reportable results don’t get you into data integrity trouble. Here’s how.

This study of PAHs makes it easy to compare this microextraction procedure to conventional approaches and to other procedures using magnetic composites.

What type of mass spectrometry (MS) instrumentation provides the best specificity during trace quantitative analysis from complex mixtures?

We review different approaches for measuring solute retention.

A look back at this innovator’s career and her efforts to develop and popularize gas chromatography (GC), particularly for biomedical research.

Click the title above to open the LCGC North America June 2018 regular issue in an interactive PDF format.

A new type of analysis called “wide-selected ion monitoring (SIM)/MS2” scanning, is capable of screening for a wide range of DNA adducts (chemical modifications to genomic DNA). This method has successfully identified DNA adducts from carcinogen exposures and oxidative stress in human prostate and kidney tissues.

An important advantage of standardized methods is that they enable comparability between laboratories and across studies. In this work, the author used a standardized targeted kit to demonstrate the accuracy, sensitivity, and reproducibility of the approach, analyzing serum samples obtained from type 2 diabetes study subjects and healthy controls.

For the BTEX compounds, detection limits in the single-digit parts-per-billion concentration range (by volume) are readily achievable within seconds using selected ion flow tube mass spectrometry (SIFT-MS), because sample analysis is achieved without chromatography, preconcentration, or drying.

Our annual review of the ASMS national conference. This year’s event was held June 3–7 in San Diego, California.

This article describes a direct analysis of glyphosate, aminomethylphosphonic acid (AMPA), glufosinate, and 3-methylphosphinicopropionic acid (MPPA) in water by liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) without derivatization.

Researchers from Merck and Agilent Technologies have developed a simple and fast generic gas chromatography–flame ionization detection (GC–FID) method for the quantitation of volatile amines in pharmaceutical drugs and synthetic intermediates.

HILIC is not straightforward and there may be a number of mechanisms in play which need to be considered.

Click the title above to open The Column June 2018 North American issue, Volume 14, Number 6, in an interactive PDF format.

Click the title above to open The Column June 2018 Europe & Asia issue, Volume 14, Number 6, in an interactive PDF format.

This Wednesday morning session will cover instrumental advances for improving signal-to-noise, digital waveform technology, ion mobility, and duty cycle, and for MS analysis of precursor and neutral loss scans and intact high m/z molecular ion analysis. It will be chaired by Randall E. Pedder of Ardara Technologies and will be held in Hall D from 8:30 to 10:30 a.m.

The award presentation for the Ron A. Hites award for an outstanding research publication in JASMS will take place on Wednesday at 4:45 pm, in Ballroom 20A on the upper level.

This Wednesday afternoon session on new research in informatics and metabolomics will be chaired by Xiaoyu Yang of NIST. It will be held in Ballroom 6CF on the upper level from 2:30 to 4:30 am.

This Wednesday afternoon session will present new research into the microbiome. It will be chaired by Trent Northern of Lawrence Berkeley National Laboratory and will be held in Ballroom 20A from 2:30 to 4:30 p.m.

This Tuesday morning session will discuss clinical and field applications of mass spectrometry, such as proteomic genotyping, detection of cancer tumors and metastases, tissue profiling, and therapeutic drug monitoring. It will be chaired by Alan Rockwood of Rockwood Scientific Consulting and will be held in Ballroom 6CF from 8:30 to 10:30 a.m.

Research awards will be presented this afternoon at 4:45 in Hall D, at the ground level, to Michael T. Marty of the University of Arizona and James S. Prell of Oregon State University. Marty received his PhD in 2013 at University of Illinois at Urbana-Champaign.