Stoichiometrically Imprinted Polymer SPE of Fluoroquinolones
October 15th 2008Researchers from Universidad Complutense de Madrid (Madrid, Spain) and Universität Dortmund (Dortmund, Germany) used a molecularly imprinted polymer (MIP) solid-phase extraction method in the analysis of fluoroquinolone antibiotics in environmental water samples.
Monolithic Spin Column Extraction of Amphetamines
October 15th 2008Researchers from Hiroshima University (Hiroshima, Japan), Hiroshima Prefectural Police Headquarters (Hiroshima), Tokai University School of Medicine (Kanagawa, Japan), and GL Sciences Inc. (Saitama, Japan) developed a spin column device packed with octadecyl silane-bonded monolithic silica for extracting amphetamines and methylenedioxyamphetamines from urine.
Thermo Fisher Scientific LC-MS-MS System Used to Detect Melamine
October 15th 2008Thermo Fisher Scientific (San Jose, California) announced that a method that uses the company?s equipment for detecting melamine and cyanuric acid in food matrixes was described in the U.S. FDA?s Laboratory Information Bulletin Number 4396, May 2007.
Waters Joins Microsoft's BioIT Alliance
October 15th 2008Waters Corporation (Milford, Massachusetts) has joined the BioIT Alliance, an initiative spearheaded by Microsoft Corporation (Redmond, Washington) that involves more than 80 pharmaceutical, biotech, laboratory instrument, and software companies working together to advance personalized medicine.
SBSE Used in Triclosan Analysis
October 15th 2008Scientists from Hoshi University (Tokyo, Japan) and the National Research Institute of Police Science (Chiba, Japan) employed stir-bar sorptive extraction (SBSE) and thermal desorption gas chromatography?mass spectrometry (GC?MS) for analyzing 5-chloro-2-(2,4-dichlorophenoxy)phenol, otherwise known as triclosan, in river water samples.
Thermo Fisher serve up food and drink at show
October 10th 2008Thermo Fisher Scientific showcased its comprehensive laboratory instrumentation and informatics solutions for food, beverage and agricultural applications at the 2008 Association of Analytical Communities (AOAC) annual meeting and exposition at the end of September...
Ask the Editor: Method Development
October 8th 2008The following question and answer were taken from LCGC Europe's "CE Currents" column (1). How should I approach method development? If possible request any details of sample stability, pKa, and solubility in different solvents and pH ranges. Information on solvents used in HPLC can also be useful.
Quick and Easy Membrane Characterization with Size Exclusion Chromatography
October 6th 2008Size exclusion chromatography (SEC) is a powerful tool for the characterization of molecules differing in size and molar mass. It is widely used and well known for the determination of molar mass distributions and molar mass averages. For membranes GPC/SEC is a useful characterization method as it can measure the membrane characteristic pore size distribution, average pore size and molecular cut-off significantly faster than other methods.
Fast Gradient LC Using Your Existing Instrumentation
October 6th 2008Transforming "standard" gradient HPLC systems into extremely fast gradient systems is readily achievable with proper application of chromatographic principles, particularly temperature control, combined with utilization of advanced HPLC columns. Bottom line: You don't have to buy a new LC to achieve ultra high quality and speed!
PerkinElmer and M. D. Anderson Cancer Center Collaborate
October 1st 2008PerkinElmer, Inc. (Waltham, Massachusetts) announced an arrangement with the University of Texas M.D. Anderson Cancer Center (Houston, Texas) that will bring the company's Array Comparative Genomic Hybridization technique to the cancer center.
Ultra-Fast Separations of Pharmaceutical Compounds with 10 mm Columns Packed with Sub-2 µm Particles
October 1st 2008Very short columns filled with 1.9 µm particles were evaluated for the ultra-fast analysis of pharmaceutical formulations. Local anæsthetic, mydriatic and anti-hypertensive agents were chosen as analytes and a method was developed and validated for each of these substances, according to ICH guidelines. Excellent quantitative performance was obtained using an optimized chromatographic system that reduces the importance of extra-column effects and cuts the analysis time to less than 15 s.
Headspace Liquid-Phase Microextraction Solvent Vapor Pressure
October 1st 2008A research group from Yanbian University and the Key Laboratory of Organism Functional Factors of the Changbai Mountain (both Yanji City, Jilin Province, China) examined the effect of the vapor pressure of the extracting solvent on the enrichment factor in headspace liquid-phase microextraction.
Mixed-Mode Cleanup Technique for Drug in Meat Products
October 1st 2008Researchers from the Technical University of Denmark and (Lyngby, Denmark) and the Danish Meat Research Institute (Roskilde, Denmark) used a mixed-mode reversed phase?anion exchange cleanup method followed by LC-MS with electrospray ionization time-of-flight detection to analyze mycophenolic acid in dry-cured ham, fermented sausage, and liver pate.
Researchers Develop 2D GC with FID Method for Determining the Make Up of Biodiesel Fuel
October 1st 2008Researchers Philip Marriott from the RMIT University (Melbourne, Australia), Warawut Tiyapongpattana, and Prapin Wilairat from the Mahidol University (Bangkok, Thailand) have developed a 2D GC with FID method for determining the composition of biofuels that extends to the C4-C24 esters. They reasoned that a 2D separation, based first on boiling point then on polarity, would provide better resolution of the components.