Heparin Removed with Chitosan Microspheres
Researchers from Jagiellonian University (Krakow, Poland) used pH-sensitive chitosan microspheres that had been cross-linked with genipin ? an aglycone derived from a compound present in gardenia fruit extract ? to bind heparin at pH levels comparable to that found in blood.
Researchers from Jagiellonian University (Krakow, Poland) used pH-sensitive chitosan microspheres that had been cross-linked with genipin — an aglycone derived from a compound present in gardenia fruit extract — to bind heparin at pH levels comparable to that found in blood. The binding was found to be pH dependent and was faster at lower pH. The chitosan microspheres swell at pH values below 6.5 and shrink somewhat at pH values greater than 6.5.
LCGC’s Year in Review: Highlights in Liquid Chromatography
December 20th 2024This collection of technical articles, interviews, and news pieces delves into the latest innovations in LC methods, including advance in high performance liquid chromatography (HPLC), ultrahigh-pressure liquid chromatography (UHPLC), liquid chromatography–mass spectrometry (LC–MS), and multidimensional LC.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
