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This study uses the challenging analysis of a complex, multi-organ peptide digest of Caenorhabditis elegans (C. elegans) to compare the performance of a novel linear ion trap mass spectrometer and a quadrupole time-of-flight (Q-TOF) mass spectrometer.

Polyacrylonitrile (PAN) is an important component of many synthetic products such as heavy-duty fibres, synthetic ropes, flame resistant plastics and clothing.

Recently a newly developed Kinetex 2.6 µm core-shell chromatographic particle has been commercialized that offers the performance benefits of sub-2 µm fully-porous particles but at substantially lower operating pressures.

In this application, we demonstrate the use of supported liquid extraction (SLE) for the extraction of beta blockers and NSAIDS from plasma compared with traditional liquid–liquid extraction. SLE was demonstrated to yield consistent LOQs using lower sample volumes.

The flexibility to use short sub-2 micron columns on UHPLC instruments at high flow-rates permits fast analysis with high resolution of complex samples. An Agilent ZORBAX Rapid Resolution High Definition (RRHD) Eclipse Plus C18 1.8 µm column separated seven different biocides in less than 1 minute with high resolution. A flow-rate of 1.7 mL/min was used on 2.1 × 50 mm column to achieve the rapid separation. The Agilent 1290 Infinity LC system was used as the column pressure just exceeded 1000 bar at this high flow-rate. A sample of hand sanitizer was found to contain 2-phenoxyethanol and methylparaben using the method.

Liquid chromatography coupled with mass spectrometry (LC–MS) is one of the most powerful analytical tools for organic compound analysis.

Hydroxyethyl starch (HES) is one of the most important plasma expanders.

Thermo Fisher Scientific has announced that a series of free on-demand webinars are available for the Chinese and Austrailian laboratory informatics communities.

Taking the pain out of chromatographic peak integration.

Here we present an updated glossary of industry terms - a handy guide for the seasoned analyst as well as those new to the field.

They say it takes several years for an awards program to really get off the ground and start amassing a history, establishing a place for itself in the industry. If this is true, then I believe we can safely say that this year, the LCGC Pittcon Awards have officially arrived. With past Lifetime Achievement Award winners such as Walt Jennings and Harold McNair, and bright young stars such as Gert Desmet and Kevin Schug claiming Emerging Leader honors over the past couple of years, there is a great deal of suspense building over who will win the 2010 awards, set to be presented at Pittcon 2010 in Orlando, Florida.

Continuing a series on peak tailing in chromatography, John Hinshaw discusses the effects that peak tailing has on quantitative measurement of peak height and area.

HTC-11 and HTSP 2010

A new proteomic profiling method based on material-enhanced laser desorption/ionization (MELDI) has been developed to identify candidate biomarkers that are selected in MELDI mass profiles. The basic principle of applying MELDI is to trace out the low-concentration species generated as a result of disease, which can then be used as diagnostic markers after their authentic validation. The first step of the MELDI approach is applied to reduce the complexity of proteomic samples by specific binding of serum proteins onto chemically modified MELDI beads, which are then directly analysed by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). The resulting mass profiles provide the basis for differentiating diseased samples from control samples. The use of liquid handling robots for sample preparation for high-throughput applications leads to higher reproducibility, which is crucial to succesfully identify disease markers. The ongoing development of MELDI for the..

Light-scattering webinars Metabolomics library Spreadsheet compliance Chemical information on an iPhone LC–MS and GC–MS deconvolution software

Remember the rule of one - change just one thing at a time.

LCGC June 2009 BPA Statement

Agilent Technologies (Santa Clara, California) announced the separation of its Life Science and Chemical Analysis Group into two businesses, Chemical Analysis and Life Sciences.

The Column speaks to the first post-Jubilee President of The Chromatographic Society - John Lough - as he completes his term of office.

Tosoh Bioscience is celebrating its 20th anniversary this year, as well as the anniversary of the company?s customer magazine.

Dionex has entered into an asset purchase agreement with ESA Biosciences that will see the company purchase its HPLC related products, HPLC clinical assays, laboratory services and assets.

Trace-Level Aliphatic Amines in Cationic Drugs - Metrohm Apps Note

CD-R Patent Protection: Brand Characterization to Identify Counterfeit Goods Using Simplified Mass Spectrometry - Waters Apps Note

Edwards new easy to install acoustic enclosure can reduce your vacuum pump?s noise level by up to 7dBA.

A fast and robust HPLC method for the simultaneous determination of ingredients in cough syrup is presented. The separation of codeine, pseudoephedrine and guaifenesin by means of reversed-phase HPLC has been found optimal.

Vitamins are biologically active compounds required for an organism?s normal health and growth.

Food, Flavour and fragrance products are well known as complex mixtures. The analyses of these matrices are carried out to determine the composition of the products, to control the quality, to determine adulteration or product counterfeiting.

Advancements to Take the Pain Out of Chromatographic Peak Integration Shaun Quinn Reducing Time and Cost with Multi-vendor Chromatographic System Control Mark Harnois, Chris Stumpf and Steven F. Eaton Meeting Review: SFC 2009 - 3rd International Conference on Packed Column Supercritical Fluid Chromatography Larry T. Taylor News Market Trends and Analysis Market Profile: Worldwide Ion Chromatography Demand Glenn Cudiamat Events

US EPA Method 200.7 ? Water Analysis - Thermo Apps NOte

Rapid sizing of nanoparticles - Paraytec Ltd Apps note