Advancements to Take the Pain Out of Chromatographic Peak Integration
Taking the pain out of chromatographic peak integration.
Peak detection and integration are fundamental tasks in chromatography. Chromatographers devote considerable time and efforts towards ensuring the accuracy and appropriateness of integration because this information is used for all subsequent calculations, such as calibrations, determining the purity of drug substances and analysis of unknowns.
Ideally, chromatographic peaks would be perfectly symmetrical with pronounced detector signal changes that clearly identify where the peak starts and ends. In reality, integration is much more complex and diverse because chromatographic data systems have to decipher many different variants and effects.
Best of the Week: Food Analysis, Chemical Migration in Plastic Bottles, STEM Researcher of the Year
December 20th 2024Top articles published this week include the launch of our “From Lab to Table” content series, a Q&A interview about using liquid chromatography–high-resolution mass spectrometry (LC–HRMS) to assess chemical hazards in plastic bottles, and a piece recognizing Brett Paull for being named Tasmanian STEM Researcher of the Year.
Using LC-MS/MS to Measure Testosterone in Dried Blood Spots
December 19th 2024Testosterone measurements are typically performed using serum or plasma, but this presents several logistical challenges, especially for sample collection, storage, and transport. In a recently published article, Yehudah Gruenstein of the University of Miami explored key insights gained from dried blood spot assay validation for testosterone measurement.
Determination of Pharmaceuticals by Capillary HPLC-MS/MS (Dec 2024)
December 19th 2024This application note demonstrates the use of a compact portable capillary liquid chromatograph, the Axcend Focus LC, coupled to an Agilent Ultivo triple quadrupole mass spectrometer for quantitative analysis of pharmaceutical drugs in model aqueous samples.
