All
Separation of Halo Acetic Acids by Ion Exclusion v2
Accurate detection of HAAs is paramount for the prevention of over oxidation, while still managing enough water sanitation to eliminate water-borne pathogens.
Flexible Anion Analysis with Hamilton PRP-X100 and X110 Columns v3
Chemically resistant resin bed allows for a wide base of mobile-phase choices with excellent anion separation.
How to Reduce the Costs of Unscheduled Instrument Downtime
Arsenic Speciation on Hamilton PRP-X100 v3
Contamination of drinking water and food sources is of great concern. Isolation and quantification of the various arsenic states are identified.
Separation of Selected Components of Ylang-Ylang Oil v2
Isolation of six common allergens by the utilization of reversed-phase HPLC using an alkaline eluent
Hexavalent Chromium Determination Hamilton PRP-X100 Anion Exchange HPLC Column v3
Chromium can pose as a beneficial element or a poison, therefore it is imperative to identify contaminated waters, especially drinking water.
Selection of UHPLC Columns for Nucleic Acid Oligomer Analysis
Synthesized 40-mer miRNA has been analyzed using both a conventional column and new types of UHPLC columns.
Isolation of Paclitaxel v2
The fight against cancer employs many tools. Paclitaxel, a compound found in the bark of the Pacific yew tree, is one that that has been found to make a big difference.
Scaling for Efficiency and Throughput: LC Method Optimization with Notes on Selectivity and Preparative LC
AssayMAP Resource Center
LC/MS Method Development for Various Oligonucleotides Using Polymer-Based HILIC Columns Having Diol Group
Quantitative Analysis for Over 100 Native and Isotopically Labelled PFAS Compounds in Drinking and Surface Water by Triple Quadrupole LC/MS
On-Demand Webcast - HPLC Troubleshooting: Conquering Common Challenges
LCGC/Agilent Resource Center - Mass Spec Automation
MHC-Associated Peptide Purification for Immunopeptidomics
Automated MHC-I is associated peptide enrichment using the Agilent AssayMAP Bravo platform with large-capacity Protein A cartridges for immunopeptidomics analysis.
Quantification and Characterization of Biotherapeutics Proteins
The AssayMAP Bravo was used to purify, digest, and clean up antibodies from 96 cell culture supernatants with high reproducibility and minimal labor prior to LC–MS.
Intact Antibody and Subunit Mass Determination
Intact and subunit antibody mass determination was streamlined using automated purification and enzymatic cleavage and deglycosylation of immobilized antibodies.
Assessing Multiple CQAs for Monoclonal Antibodies v2
Automated sample prep and LC–MS peptide mapping approach to characterize and quantify multiple monoclonal antibody (mAb) critical quality attributes (CQAs)
Automated Phosphopeptide Enrichment from Complex Mixtures
Automated phosphopeptide enrichment from cell lysates with Fe(III)-NTA enables the identification of thousands phosphopepides with high reproducibly and selectivity.
Ion Mobility Mass Spectrometry Phosphopeptide Analysis
Automated phosphopeptide enrichment and ion mobility mass spectrometry (IMS-MS) enables detailed analysis of structural effects of site-specific phosphorylation.
Streamlining DAR Determination for ADCs
Automated Antibody Drug Conjugate (ADC) purification and deglycosylation increases reproducibility and simplifies drug-to-antibody ratio (DAR) determination
Host Cell Protein Analysis
Improved host cell protein analysis using highly reproducible and scalable automated sample digestion and fractionation ahead of LC–MS coupled with iterative MS–MS
Liposome Structure and Concentration by FFF-MALS-DLS
Field-flow fractionation with online static and dynamic light scattering constitutes a powerful and versatile system for nano-pharmaceutical characterization.
Application Note: Monitoring Product-Related mAb Fragments
This application note presents a reversed-phase LC method capable of separating all relevant reduction-induced LMW species of the NISTmAb.
Robust and Sensitive PFAS Screening
Get a better understanding of how combustion ion chromatography is an effective and sensitive analytical technique for AOF.
Extending the Quantitative Performance for Haloacetic Acids (HAAs), Bromate, and Dalapon in Water Using an IC–MS/MS workflow
Easily implement a robust, reliable, and reproducible workflow solution for the analysis and quantitation of nine HAAs, bromate, and dalapon in water using IC–MS/MS.
Optimizing Control of Pump-Related Biopharma-Production Processes
This application note will illustrate how a new integrated pump controller is giving users automated control of pump operations in critical biopharma applications.
New Standards for Bottom-up Proteomics
This application note reveals the Vanquish Neo offers maximal MS utilization for direct injection workflows and versatility to separate peptides at low flow rates.
Ultra-Robust High-Throughput Peptide Quantification
This application note shows a micro-flow LC–MS method developed on the Vanquish Neo UHPLC is suitable for high-throughput proteomic analyses of large sample cohorts.
Recent Developments in Biopharmaceutical Analysis (Europe)