Application Notes

This application note describes two methods for isopropyl alcohol impurities detection: USP recommended 42-min analysis, and a speed-optimized method in less than 6 min.

UniSpray is a novel atmospheric ionization technique that provides increased peak response, enabling ultra-trace detection of PFAS and other contaminants.

Purification of peptide-peptoid hybrids can be obtained by reversed-phase chromatography with excellent recovery and resolution.

The ability to collect compounds is related to the ability to detect them. Many possess weak or non-existent chromophores, causing UV detection to exhibit poor yields. 

Purification of a single-stranded RNA oligonucleotide by ion pair reversed-phase HPLC is demonstrated, achieving > 99% pure fraction pool with a yield of > 56%.

This app note introduces the use of the Nexera XS inert UHPLC, which utilizes a metal-free flow path for accurate and reproducible analysis of nucleotides.  

This technical report covers how a column packed with small particle material can be used to optimize an analytical method for monoclonal antibody aggregates. 

Using high-capacity sorptive extraction with TD–GC–MS analysis for flavour profiling of cider and potato chips, contrasting unflavoured and flavoured-added products

This app note introduces an analytical method for the separation of oligonucleotides of different length by ion-exchange chromatography using the Nexera XS Inert. 

This app note covers aggregate analysis using a Shimadzu Shim-pack™ BioDiol size-exclusion chromatography column with the Nexera XS inert UHPLC.  

This technical note shows how the PreOmics BeatBox enables the processing of large sample cohorts efficiently in as little as 10 min without sample cross-contamination.

This application note is the first reported separation of Fluoxetine on polysaccharide-based chiral HPLC columns, and it comes on Daicel’s newest column, CHIRALPAK® IK.

This application note features a unique, simple, and robust solid-phase extraction method for cannabinoids in urine followed by analysis by LC–MS/MS.

A novel LC approach to manipulate the chromatography of closely related PFAS analytes to separate co-elutes and avoid matrix interferences.

Application guide to PFAS analysis in environmental and food samples, from sample preparation to LC–MS/MS analysis, featuring both validated and exploratory methods

A municipal wastewater laboratory demonstrates the use of QuEChERs sample preparation techniques to analyze PFAS in sediments at sub ng/g levels.

A novel sample preparation technique to reduce sample preparation time, material cost, and labor cost, thereby increasing laboratory productivity and sample throughput as compared to the traditional two-step sample preparation process.

A study done in collaboration with the Orange County Water District (OCWD) for a direct comparison of manual vs. automated SPE sample preparation in EPA method 537.1