Scaling for Efficiency and Throughput: LC Method Optimization with Notes on Selectivity and Preparative LC

Deriving antibodies from plasma involves a multi-step process, from plasma collection to antibody purification and quality control, ensuring the final product is safe and effective for therapeutic, diagnostic, or research use. Krish Gosh, PhD, MBA, President of TCG Digital, joined LCGC International to discuss how AI/GenAI applications can optimize several steps to enhance yield, profitability, and process monitoring.

An extraction method with an optional fluorenylmethyloxycarbonyl chloride derivatization step to allow for the analysis of glyphosate on a C18 HPLC column.

Evaporation enhances method sensitivity. This study investigates the impact of gas temperature and flow rate on blowdown evaporation of solvents and their mixtures

LC-MS/MS method for low level quantitation of seven PFAS listed in the National Academies of Science and Engineering recommendations for clinical research.

Combining a Phenomenex Gemini C18 LC column High Resolution, high accuracy mass spectrometry was used to resolve interferences observed during analysis of PFAS in plasma and serum.

Comparison of blood collected using volumetric absorptive microsampling (VAMS) and serum for LC-MS/MS for analysis of a comprehensive PFAS panel