Application Notes

In this work, an LC–MS/MS method is presented for the analysis of 66 pesticides and five mycotoxins in cannabis and hemp concentrate.

This validation study demonstrates the use of the QSight® tandem quadrupole mass spectrometer (LC–MS/MS) for the application of PFAS EPA Method 537.1 in drinking water.

SEC-MALS quantifies biophysical attributes of mRNA including molar mass, percent aggregates, Rg and Rh, and how they are affected by formulation and storage conditions.

This white paper presents the characterization of protein-DNA complexes using two complementary multi-angle light scattering techniques, SEC-MALS and CG-MALS.

IEX-MALS overcomes some of the restrictions of SEC-MALS that arise from SEC, while providing absolute molar mass, size, and quality assessment of heterogeneous proteins.

This application note demonstrates a method for sampling and analyzing VOC emissions of essential oils from in-home diffusers by using the TD–GC–MS method.

This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retrovial viral vectors.

SEC-MALS identifies monomers, dimers, hexamers, and higher aggregates of insulin to determine optimal formulation, storage, and administration conditions.

Wyatt’s instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.

Branching analysis of amylopectin requires a linear amylose analog. Synthetic amylose was prepared and characterized by SEC-MALS to determine if branching is present.

This application note demonstrates Evolved Gas Analysis (EGA) and Multi-step Pyrolysis (MSP) with GC-MS on cyanoacrylate glues.

Accelerate deconvolution of complex MS samples with software that generates an extensive, unbiased, relevant list of structures and component identifiers for your data.

This application note demonstrates a streamlined HPLC method scouting workflow for the analysis of esomeprazole and related degradation products.

A YMC-Triart C18 and a YMC-Triart SIL column were used in RP and NP mode, respectively, for the analysis of four different phosphoramidites.

The recently introduced 1 mm YMC-Triart C18 UHPLC column was used for the high sensitivity LC–MS screening of six antineoplastic drugs.

A YMC-Triart C18 and a YMC-Triart SIL column were used in RP and NP mode, respectively, for the analysis of four different phosphoramidites.

Mipomersen was analyzed by LC–HRMS using a biocompatible YMC-Triart C8 metal-free column, ensuring symmetric peaks, high sensitivity, and no carryover effects.

The separation of three cell-penetrating peptides (CPPs) was performed using a YMC-Triart C18 UHPLC column, providing sharp peaks for a fast analysis in under 4 min.

Twenty-eight PFAS in human serum were analyzed using a YMC-Triart C18 column. An automated SPE system was coupled to an online SPE column-switching LC–MS/MS method.

Four hydrophilic dipeptides were separated with excellent resolution using a YMC-Triart SIL column. Even structurally similar dipeptides were separated in under 4 min.

The UHPLC analysis of four cyclic peptides is shown. Based on the hydrophobicity of the peptides, a YMC-Triart Bio C4 UHPLC column was chosen for this application.

The analysis of FMOC-derivatized glyphosate and AMPA in water samples was performed using a YMC-Triart C18 UHPLC column at an elevated pH of 9.5.

Methods migration from updating analytical equipment can be a time consuming task. This paper shows many examples of method compatibility and analytical equivalency.

LC–MS workflow for accurate quantification/detection of individual host cell proteins, from sample preparation to the reporting of values of process-related impurities.

Efficient and accurate HPLC analysis of lamotrigine in compliance with USP