Application Notes

Learn how machine learning and artificial intelligence enable new capabilities in proteomics data processing to increase throughput and depth of coverage.

This technical note demonstrates the screening capabilities of Thermo Scientific™ Orbitrap Exploris™ 120 mass spectrometer’s accurate analysis of 212 fentanyl compounds

Mass spectrometry (MS) based proteomics is a promising technique for single-cell analysis by enabling the identification and quantification of thousands of proteins in an unbiased manner.

New infographic to discover optimized workflows utilizing leading Thermo ScientificTM instruments, consumables, and software for AAV product and process characterization.

A well-thought-out and detailed grant proposal is essential to the success of the application. Here are 7 steps in the grant-writing process to help you reach new heights.

In-Depth Label-free analysis of single mammalian cells with nanodroplet single processing

This document reveals integration of LC-MS with an on-line advanced mass spectral database to enable faster development of acquisition methods.

This App Note discusses ultra-sensitive quantification of antibody biotherapeutics and biomarkers with a novel trapping-microLC-FAIMS/SRM-MS strategy.

In this new infographic, discover optimized workflows utilizing leading Thermo ScientificTM instruments, consumables, and software for AAV product and process characterization.

App Note discusses improving the limit of quantification of sulfonamides in complex meat muscle extract by incorporating FAIMS technology into the LC/MS workflow.

This technical note provides discovery to quantitation workflows for COVID-19-infected individuals by monitoring two biological matrices – plasma and nasopharyngeal swab

Developing an analytical method that merges 3 conventional LC-UV methods into 1 LC-MS/MS method, improving laboratory productivity while maintaining high data confidence.

This illustration provides a brief chronology of single-cell proteomics.

This Tech Note evaluates data-independent acquisition performance on the Thermo Scientific™ Orbitrap Exploris™ 240 MS for quantitative discovery proteomics analysis.

Using a mass spectrometer as a gas chromatography (GC) detector has many advantages for compound identification and quantification, but there is another less-known benefit: speeding up analyses by using the mass spectrometry (MS) vacuum to lower pressure within the column. This technique, also known as “vacuum‑outlet GC” or “low-pressure GC–MS” (LPGC–MS), can provide significant gains for fast GC–MS.

This application note demonstrates the performance of the SCION LC6000 HPLC for the analysis of cannabis potency.

Pesticide testing is crucial to assessing the safety of fruits and vegetables for consumption. The traditional extraction method for pesticides from produce is the QuEChERS method. This method is tedious, manual, time consuming, and wasteful. Thus, there is a need for improved methods of extraction. In this application note, the EDGE®, in combination with Q-Matrix™ Hydra, a water-removing sorbent, was used to extract a panel of pesticides from 10 g of homogenized cucumber, tomato, and green pepper in less than 9 min. The recoveries of the pesticide panel were greater than 70% for each matrix tested, and these results were highly reproducible. The EDGE provides a fully automated extraction that combines both the sample and sorbent into one sample vessel, alleviating the human burden of extraction and the need for multiple sample transfers.

Mirtazapine is an approved antidepressant, with other studies exploring its use to treat sleep apnea, substance abuse withdrawal symptoms, and as an antihistamine.

Monoclonal antibodies (mAbs) are effective therapeutics for cancers, auto-immune diseases, viral infections, and other diseases. Recent developments in antibody therapeutics aim to add more specific binding regions (bi- and multi-specificity) to increase their effectiveness and/or to downsize the molecule to the specific binding regions (for example, scFv or Fab fragment) to achieve better penetration of the tissue. As the molecule gets more complex, the possible high and low molecular weight (H/LMW) impurities become more complex, too. In order to accurately analyze the various species, more advanced detection than ultraviolet (UV) is required to characterize a mAb sample.

Yoghurt aroma compounds and comprehensive profiles are determined using solvent swollen PDMS-Twisters for solvent assisted SBSE followed by Liquid Desorption-GC/MS, sensory assessment, and multi-variate analysis-based classification.