Application Notes

Monoclonal antibodies (mAbs) are effective therapeutics for cancers, auto-immune diseases, viral infections, and other diseases. Recent developments in antibody therapeutics aim to add more specific binding regions (bi- and multi-specificity) to increase their effectiveness and/or to downsize the molecule to the specific binding regions (for example, scFv or Fab fragment) to achieve better penetration of the tissue. As the molecule gets more complex, the possible high and low molecular weight (H/LMW) impurities become more complex, too. In order to accurately analyze the various species, more advanced detection than ultraviolet (UV) is required to characterize a mAb sample.

Yoghurt aroma compounds and comprehensive profiles are determined using solvent swollen PDMS-Twisters for solvent assisted SBSE followed by Liquid Desorption-GC/MS, sensory assessment, and multi-variate analysis-based classification.

Guide to PFAS testing in food and food contact materials that require more extensive analytical preparation techniques, compared to PFAS testing of drinking water

Complete selection of applications for pesticides and semi-volatiles testing by EPA methods demonstrates high resolution and quality of analysis

Application guide to PFAS analysis in drinking water by EPA methods 533 and 537.1, from sample preparation to LC-MS/MS analysis, featuring both validated and exploratory methods.

The latest applications and resources for testing cannabis potency, pesticides, mycotoxins, terpenes, and residual solvents.

Novel sample preparation technique to reduce sample preparation time, material cost, and labor cost, thereby increasing laboratory productivity and sample throughput

Get the answers to the PFAS most common analytical challenges on sample collection, extraction, methods, and decontamination procedures to ensure PFAS quality analysis.

This application note outlines an extraction method for four natural cannabinoids and the two major metabolites of Δ9-THC in blood using Clean Screen® THC SPE column.

Analysis of trace per- and polyfluorinated organic vapours in air using cryogen-free thermal desorption and gas chromatography–mass spectrometry.

Thermal desorption–GC×GC-TOF–MS can be used to characterise volatiles from recycled plastics and the method is simple to translate to routine screening in QC labs.

Headspace sampling using HiSorb probes for solvent-free high-capacity sorptive extraction combined with GC–MS analysis for flavour profiling foods and beverages.

This application note covers a non-derivatization LC–MS/MS method for determining total proteinogenic amino acids and taurine amounts in infant/adult milk formulas.

GC×GC with BenchTOF2 mass spectrometry and powerful software provide comprehensive non-target screening of liquid smoke composition to improve quality control.

This application note shows how thermal desorption–GC–MS was used to address multiple challenges in the detection of microplastics in different salt samples.

This application note introduces a sensitive simultaneous analysis method for lactose, allolactose, lactulose, and, six other saccharides.

High-throughput GC–MS analysis of contaminant 1,4-dioxane in water using SPME Arrow–trap with multi-step enrichment on the Centri extraction and enrichment platform.

In this application note we used a GCMS-TQ8050 NX to perform SIM and MRM analysis of 3-MCPD, 3-MCPD fatty acid esters, and glycidol fatty acid esters in powdered milk.

This application note covers the use of a method package to assess the safety level of several meat samples, eggs, and milk.