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Streamlining DAR Determination for ADCs
Automated Antibody Drug Conjugate (ADC) purification and deglycosylation increases reproducibility and simplifies drug-to-antibody ratio (DAR) determination
Host Cell Protein Analysis
Improved host cell protein analysis using highly reproducible and scalable automated sample digestion and fractionation ahead of LC–MS coupled with iterative MS–MS
Liposome Structure and Concentration by FFF-MALS-DLS
Field-flow fractionation with online static and dynamic light scattering constitutes a powerful and versatile system for nano-pharmaceutical characterization.
Application Note: Monitoring Product-Related mAb Fragments
This application note presents a reversed-phase LC method capable of separating all relevant reduction-induced LMW species of the NISTmAb.
Robust and Sensitive PFAS Screening
Get a better understanding of how combustion ion chromatography is an effective and sensitive analytical technique for AOF.
Extending the Quantitative Performance for Haloacetic Acids (HAAs), Bromate, and Dalapon in Water Using an IC–MS/MS workflow
Easily implement a robust, reliable, and reproducible workflow solution for the analysis and quantitation of nine HAAs, bromate, and dalapon in water using IC–MS/MS.
Optimizing Control of Pump-Related Biopharma-Production Processes
This application note will illustrate how a new integrated pump controller is giving users automated control of pump operations in critical biopharma applications.
New Standards for Bottom-up Proteomics
This application note reveals the Vanquish Neo offers maximal MS utilization for direct injection workflows and versatility to separate peptides at low flow rates.
Ultra-Robust High-Throughput Peptide Quantification
This application note shows a micro-flow LC–MS method developed on the Vanquish Neo UHPLC is suitable for high-throughput proteomic analyses of large sample cohorts.
Recent Developments in Biopharmaceutical Analysis (Europe)
Recent Developments in Biopharmaceutical Analysis
Developing Analytical Methods with a Focus on Genotoxic Impurities
New Frontiers in Cannabis and Hemp Testing, Part 2
Extraction of Synthetic Benzodiazepines from Urine
The hydrolysis and SPE steps were combined for designer and pharmaceutical benzodiazepines from urine along with a fast quantitative LC–MS/MS method.
Automated MHC-Associated Peptide Enrichment for Immunopeptidomics Analysis
Reduce Variability and Increase Productivity with Automated Protein Sample Preparation
Agilent AssayMAP Bravo Technology Enables Reproducible Automated Phosphopeptide Enrichment from Complex Mixtures Using High-Capacity Fe(III)-NTA Cartridges
A streamlined drug-to-antibody ratio determination workflow for intact and deglycosylated antibody-drug conjugates
Agilent AssayMAP Bravo Citation Index
Comparing SLE Sorbents for Steroids from Plasma
A low-level extraction of steroids using Novum PRO SLE is performed and compared with another SLE product for the baseline cleanliness.
AssayMAP Bravo Automated Protein and Peptide Sample Preparation Platform
Microchip CE-MS Charge Variant Analysis for NIST mAb and Transtuzamab
ZipChip CE-MS offers a fast and easy method for native charge variant analysis and product monitoring workflows that are often challenging with traditional LC-MS.
Case Study: TGA-FTIR-GC/MS to Advance Microplastics Research
Direct Analysis of Trace Elements in Open-Ocean Seawater using the NexION 5000 ICP-MS
Surveying LC Columns for Levetiracetam Analysis
A variety of C18-type columns are evaluated for the identification of levetiracetam via the USP monograph.
HPLC Analysis of Levetiracetam Organic Impurity
Symmetrical, well-resolved peaks easily meet USP performance requirements for the analysis of levetiracetam impurities.
HPLC Analysis of Pramipexole Dihydrochloride
Symmetrical, well-resolved peaks easily meet USP performance requirements for the analysis of pramipexole dihydrochloride.
HPLC Analysis of Amlodipine Besylate
Easily meet USP method requirements with reduced backpressure using a larger ID column.
Surveying LC C18-Type Columns for Hydrocortisone Analysis
A variety of C18-type columns are evaluated for the identification of hydrocortisone via the USP monograph.
Application Note: GC–MS Analysis of Volatile Green Residual Solvents
The pharma industry is embracing the challenge of sustainability by using greener solvents. A GC–MS method for analyzing 32 green solvents is presented.
