Application Notes: Pharmaceuticals

H2 is commonly used as GC carrier gas as the cost of He is increasing and its availability is decreasing. In addition to the cost/availability issues, H2 can provide more rapid separations at lower temperatures than He and provides longer column life. H2 gas is obtained by the electrolysis of water and many laboratories supply it to the GC via an in-house H2 generator.

Tosoh Bioscience LLC

Hyaluronic acid (HA) is a ubiquitous, very high molar mass polysaccharide that has been of particular importance in opthalmic surgery. HA acts as a molecular "shock-absorber" and stabilizer for cells and its visco-elastic properties are valuable for separating tissue and maintaining shape.

A novel method for Drug Antibody Ratio determinations based on SEC-MALS in conjunction with UV absorption and differential refractive index detection.

CUSTODION SPME Syringes provide a simple, low cost methodology to collect and introduce samples to an analytical instrument. The low cost and convenience of SPME allows multiple samplers to be deployed simultaneously.

Method 525.3 is similar in many ways to its predecessor, method 525.2 (Rev 2.0 – 1995), however there are significant changes which make the newer 525.3 a vastly improved method during sample collection, extraction, and analyzing.

LC–MS-MS has become an important tool to assess an individual's vitamin D status. Chromatographic resolution of the various homologs of vitamin D2 is necessary for accurate quantitation since several key metabolites are isobaric and not distinguishable by MS alone.

OI Analytical

A commercially available monoclonal antibody was analyzed via three different particle sizes (5 ?m, 3 ?m, and 2 ?m) to investigate the effects of particle size on resolution and the ability to increase sample throughput.

Imtakt USA

Due to increased concern over the hydrofracturing process and the release of methane and other chemicals into the local drinking water, a need has developed for fast and accurate analysis of methane in water.

The update to the SANCO guidelines in 2009 recognized the power and potential of TOF mass spectrometry for pesticide screening applications. When compared with historical screening tools (such as the use of triple-quad mass spectrometry), high performance accurate mass TOF systems offer several advantages for screening applications.

PHOTONIS USA

The Hamilton PRP-C18 is a new column designed to provide high-efficiency reversed phase separations over an extended column life in nearly any mobile phase or pH. The rigid stationary phase has excellent mechanical and thermal stability (> 100 ?C), does not experience shrinkage or swelling and is completely inert to most conditions commonly encountered in reversed phase chromatography. In this study the pH stability of the PRP-C18 is evaluated. Even after prolonged exposure to concentrated (1 molar) NaOH and H2SO4 there was no measurable deterioration in performance.

Agilent Technologies

Agilent Technologies

Waters Corporation

Agilent Technologies

Waters Corporation

Hamilton Company

Tosoh Bioscience LLC

Pickering Laboratories, Inc.

Agilent Technologies Inc.

Hamilton Company

UCT, LLC

Supelco/Sigma-Aldrich

Waters Corporation

FMS, Inc.

Regis Technologies, Inc.

Proton OnSite