“Separation Science: Driving Pharmaceutical Development and Manufacture” The Chromatographic Society Annual Spring Symposium
The Chromatography Society’s (ChromSoc) annual Spring Symposium “Separation Science: Driving Pharmaceutical Development and Manufacture” will take place on 9 May 2019 in Sunderland, UK.
The Chromatography Society’s (ChromSoc) annual Spring Symposium “Separation Science: Driving Pharmaceutical Development and Manufacture” will take place on 9 May 2019 in Sunderland, UK. The programme will involve presentations from academics and pharmaceutical industry analysts on the UK development and manufacturing context, the scope of applications, the role of pharmacopoeia, the effective use of liquid chromatography (LC) in quality control, bioanalysis, and biopharmaceuticals, and examples of the use of modern LC technology in development and manufacturing. Before the meeting, analytical scientists supporting pharmaceutical development and manufacturing were invited to comment on the most important unmet analytical needs they are facing. Arising from this, for the main part of the afternoon session, speakers, and in particular vendors, will be set the task of demonstrating how the following identified challenges might be met:
- The sheer number and variety of molecular entities coming through development and manufacture;
- The range and variety of formulations now being encountered;
- The need for automation in sample preparation for development and manufacture;
- Taking greater utilization of preparative LC in pharmaceutical development and manufacture;
- Training.
These themes will take up a large part of the afternoon session and at the close of the meeting a panel discussion will be held to consider whether these challenges are being satisfactorily addressed. Registation:https://goo.gl/meK4UT
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
