All News
Monitoring High Blood Pressure Treatment with HPLC–MS–MS
June 6th 2014A new study in the journal Heart suggests that high performance liquid chromatography tandem mass spectrometry (HPLC?MS?MS) can be performed as a standard screening tool to identify patients who do not take the anti-hypertensive medications as prescribed by their doctor.1
Tips & Tricks GPC/SEC: The Art of Analyzing High Molar Mass Samples
June 6th 2014GPC/SEC can be performed for samples that range from a few hundred to several million daltons in molar mass. It can often require more skill to analyze high molar mass samples in the molar mass range of several million dalton. This article explains more.
UHPLC–ESI–MS–MS Detects Cavity Fighting Compounds in Red Wine
June 6th 2014Red wine could help to protect against oral cavities, according to research published in the Journal of Agricultural and Food Chemistry.1 The team used ultrahigh-pressure liquid chromatography tandem mass spectrometry together with electrospray ionization (UHPLC–ESI–MS–MS) to analyze phenolic compounds found in the sampled red wine.
Today's Plenary: Award Lecture by Richard M. Caprioli
June 6th 2014Today?s plenary is an award lecture by Richard M. Caprioli of Vanderbilt University. Caprioli is the recipient of the 2014 ASMS Award for a Distinguished Contribution in Mass Spectrometry for the development of matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry and its application to molecular mapping of tissues in biology and medicine. His award lecture today will be held in Exhibit Hall AB, at 4:45 pm.
Monday Morning Session Preview: Emerging Environmental Contaminants
June 6th 2014Matthew Crowe, of Dow Chemical (Midland Michigan), will preside over six Monday morning oral sessions on ?Emerging Environmental Contaminants.? The sessions will take place in Exhibit Hall AB between 8:30 a.m. and 10:30 a.m.
Sense and Sensitivity: The Role of Separation Science in Sensory Evaluation
June 6th 2014Kate Mosford of The Column spoke to Giorgia Purcaro of the Department of Food Science at the University of Udine, Italy, and Chiara Cordero of the Department of Drug Science and Technology at the University of Turin, Italy, about the sensory evaluation of olive oil and the benefits of a comprehensive approach.
Electrophoretic and Microfluidic Separation Approaches for DNA Analysis
June 5th 2014DNA can be analyzed by many techniques, including electrophoretic techniques such as gel, capillary, and microchip electrophoresis, and nanochannel methods in which DNA is labeled and stretched. This interview with Kevin Dorfman, an Associate Professor in the Department of Chemical Engineering and Materials Science at the University of Minnesota in Minneapolis, Minnesota, discusses his research with polymer physics and microfluidic and nanofluidic technologies.
Sample Preparation for Chromatographic Methods in Metabolomics
June 4th 2014Advances in mass spectrometry instrumentation have opened up the field of metabolomics, but there are still issues with non-standardized sampling and sample preparation methods. Tuulia Hyötyläinen from the VTT Technical Research Centre of Finland discusses the vast range of sample matrices and gives advice on best practices.
Determination of Acrylamide in Water by Liquid Chromatography Coupled to Tandem Mass Spectrometry
June 1st 2014An analytical method based on liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) has been developed for the determination of acrylamide in water. To obtain clean extracts and low detection limits, an activated carbon cartridge was investigated for use in solid-phase extraction (SPE), and extraction conditions such as desorption solvent and elution volume were optimized by a series of experiments. High recoveries (99.1–99.8%) were obtained using the activated carbon solid-phase extraction cartridges with methanol as the eluent. This method could be applied to the quantification of acrylamide in environmental water samples.
Exploring the Possibilities of High-Throughput Sample Preparation
June 1st 2014Sample preparation has often been viewed as the bottleneck in analytical procedures. Surveys have shown that time is typically the most frequent problem area for sample preparation procedures. While newly developed extraction techniques address time, modern chromatography advances are also moving towards faster separations. Based on these considerations, what is high-throughput sample preparation? Do modern extraction methods adequately address the issue of time? How can we address the analytical need for speed?
Superficially Porous Particles: Perspectives, Practices, and Trends
June 1st 2014This review provides an updated overview of the theory behind the success of SPP technology, trends, benefits, and limitations. It also summarizes the latest developments of sub-2-?m SPPs and instrumental constraints associated with their use.
Investigating the Origins of Metabolism
May 29th 2014Scientists at the University of Cambridge (Cambridge, UK) have reconstructed the early conditions of the Earth?s oceans to find that spontaneous chemical reactions could have generated the first biological molecules, before the evolution of organisms or the existence of enzymes.1 The study published in the journal Molecular Systems Biology presents data collected from liquid chromatography?triple quadrupole mass spectrometry (LC–QTOF–MS) suggesting that reactions central to our core metabolism could have spontaneously occurred.
