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A new study in the journal Heart suggests that high performance liquid chromatography tandem mass spectrometry (HPLC?MS?MS) could be performed as a standard screening tool to identify patients who do not take the anti-hypertensive medications as prescribed by their doctor. 1 The authors suggest that up to one in four patients is misdiagnosed as suffering with ?resistant hypertension?, when in fact the patient has not been taking their prescribed medications as advised.1

Many troubleshooting investigations in chromatography often don?t lead to a single causal factor. Often, the reason for problems or lack of method robustness are related to many small ?contributory factors? and this is particularly true of the problems associated with sample introduction in capillary Gas Chromatography.

The latest newsletter from May 15.

A study published in the journal Environmental Science and Technology suggests a strong link between oil and gas emissions and the high production of ozone in the atmosphere during the winter months in the Uintah Basin in Utah, USA.1 Scientists from the Institute of Arctic and Alpine Research (INSTAAR) at the University of Colorado in the USA performed continuous measurements of ozone, methane, and a suite of nonmethane hydrocarbons (NMHCs) above the basin between January and February in 2012 and 2013.

Steroid testing is commonly associated with sports doping testing to monitor athletes for performance-enhancing compounds, but it also important in the food industry for consumer safety. A new method using high-temperature liquid chromatography with photodiode detection and isotope ratio mass spectrometry (HT?LC?PDA?IRMS) that does not require sample derivatization and uses water as the eluent has been developed by scientists at the University of Duisberg-Essen in Essen, Germany.1

The 2014 Lifetime Achievement in Chromatography Award is granted to Fred E. Regnier. Here we chart his career and accomplishments.

Mohamed Abdel-Rehim, professor of analytical chemistry at Stockholm University in Stockholm, Sweden, spoke to Bethany Degg of The Column about a novel approach to determine drug intake using saliva samples.

An excerpt from LCGC's e-learning tutorial on core–shell particles for HPLC at CHROMacademy.com

Benzodiazepines are extensively misused as a result of their hypnotic-sedative properties and relative availability, and they are often used in combination with other drugs, which can result in life-threatening conditions. This article presents a SPE and LC–MS method for the analysis of benzodiazepines in synthetic urine samples.

Click the title above to open The Column May 12, 2014 North American issue, Volume 10, Number 8, in an interactive PDF format.

Click the title above to open The Column May 12, 2014 Europe & Asia issue, Volume 10, Number 8, in an interactive PDF format.

We all make mistakes. The first step to correcting them is recognizing them, and learning the right way to do things. Merlin Bicking talks about two common errors, and how to avoid them.

Click here to view the complete E-Separation Solutions newsletter from May 8, 2014.

Solid-phase extraction (SPE) is a versatile and reliable technique that is often used for sample cleanup and concentration. Kevin Schug offers some insight about SPE basics and achieving successful extractions.

The latest newsletter from May 8.

Peak Scientific (Inchinnan, Scotland) has been awarded a 2014 Queen?s Award for Enterprise in International Trade decreed by Her Majesty The Queen of Great Britain, on the recommendation of the Prime Minister, David Cameron. The awards are announced each year on the Queen?s birthday, 21 April.

Steroid testing is commonly associated with sports doping testing to monitor athletes for performance-enhancing compounds, but it also important in the food industry for consumer safety. A new method using high-temperature liquid chromatography with photodiode detection and isotope ratio mass spectrometry (HT?LC?PDA?IRMS) that does not require sample derivatization and uses water as the eluent has been developed by scientists at the University of Duisberg-Essen in Essen, Germany.1

This Monday afternoon session will be chaired by Koji Otsuka of Kyoto University, in Japan.

In today?s program, Ron Majors of LCGC, Fabrice Gritti of the University of Tennessee, and David S. Bell of Supelco/Sigma-Aldrich will each present a free tutorial session.

In today?s free tutorials, several very practical topics will be covered, including theoretical and practical aspects of UHPLC, the role of dwell volume in UHPLC method transfer, and how regulations are changing the role of separation sciences

Fabrice Gritti of the University of Tennessee in Knoxville, Tennessee, will preside over this Tuesday morning session.

Jonathan Sweedler of the University of Illinois in Champaign, Illinois, will chair this Monday morning session.

Past, present, and future developments of supercritical fluid extraction (SFE) are outlined. New vendor activity in terms of automation and hyphenation with chromatographic separations is discussed.

This article introduces some of the concepts behind green chemistry, covering solvent selection and extraction techniques.

The current status of superheated water extraction is reviewed, and the extraction methods, applications, and problems encountered are discussed.

Current advances in commercial pressurized-fluid extraction (PFE) instrumentation are discussed, along with the advantages of performing PFE prior to chromatographic analysis.

The author reviews the automation capabilities available, and some practical considerations to take into account when choosing to automate some or all of the sample preparation and handling steps that must be done before analysis.

This month's "LC Troubleshooting" instalment looks at two reader-submitted questions regarding method calibration.

Microwave-accelerated extraction (MAE) is described and evaluated. The latest enhancements to this technology are discussed from a hardware and applications perspective.

The session chair for this Wednesday afternoon session is Chao Yan of Shanghai Jiao Tong University (China). The session will be held in room HEC-C in the Hilton Exhibition Center on the second floor of the Hilton, beginning at 1:30 p.m.