Application Notes

Amylose is an occasionally branched biopolymer and, together with amylopectin, the hyper-branched component, a constituent of starch. Determination of branching in amylopectin, an important property affecting viscosity, stiffness, and thermo-mechanical performance, requires a fully linear amylose analogue. This application note describes how synthetic amyloses from enzymatic (phosphorolytic) reaction were checked for their linearity using size-exclusion chromatography-multi-angle light scattering (SEC-MALS).

Antisense DNA and siRNA are widely used for gene silencing in research and medical applications. An effective delivery of the oligonucleotides into cells is important for clinical applications.

This application note demonstrates the transfer of analytical HPLC methods from an Agilent 1260 Infinity LC system to the Vanquish Core HPLC system.

This application note demonstrates the transfer of analytical HPLC methods from a Waters Alliance HPLC system to the Vanquish Core HPLC system.

The molecular similarity between Humira® and Yervoy® biosimilars and the corresponding innovator reference products is examined using analytical SEC, RPC and HIC.

· Traps and “delays” system-related PFAS, preventing interference · Allows accurate identification and quantitation of trace-level PFAS · Highly retentive-no breakthrough even with extended equilibration times

-High-efficiency source in GC/MS: using sensitivity to enhance productivity -Simultaneous analysis of volatile organic compounds and 1,4-dioxane -Industry challenges and the importance of reliable, robust technology

A focus on research scientist and analytical chemist, Diana Jaeger, analyzing samples using LC/TQ for River Stone Biotech, a new player in synthetic biology.

A simple and sensitive method is presented for the direct analysis of Glyphosate and AMPA in drinking water without sample derivatization or pre-concentration.

This application note outlines a simple SPE procedure for the extraction of 26 diverse per- and polyfluoroalkyl substances (PFASs) in drinking water.

This white paper discusses the advantages of using fast, efficient HALO® Fused-Core® Technology columns and manipulating selectivity to quickly develop methods, for fast high efficiency LC and LCMS separations.

The evaluation of a system for automatic preparation and documentation of 100% comparable standards

Simple sugars ribose and xylose (are easily and quickly separated on a very stable amide column using high acetonitrile concentration in the mobile phase.

• Special considerations when updating software • Data integrity challenges in the cloud environment • Implications of moving to the cloud with respect to audits

• Validating custom calculations • The importance of a second-person review and locking data • How to compile a data-integrity plan · · ·

This RAFA 2019 winner of the Best Poster Award, reviews the identification and characterization of secoiridoids isomers found in Greek extra virgin olive oil (EVOO).

Note discusses how labs are coping with the worldwide helium shortage.

The metabolites from an infection of the fungus, Aspergillus flavus in foods are known to be toxic to human life, infected food needs to be identified.

Study demonstrating the development of an analytical platform based upon TD–GC×GC–TOF MS and showing its application to the collection and analysis of breath samples

* Analysis of pesticides in complex food matrices * Nontargeting screening for food adulterants/contaminants * Food authenticity testing with LC/Q-TOF

Automated GC/MS determination of 3-MCPD and glycidol in edible oils. Evaporation step helps reach required LODs with standard MSD and removes excess derivatization reagent for improved stability.

PharmaFluidics introduces a new µPAC™ capLC column that offers unprecedented performance and that given its low back pressure can be used up to flow rates of 15 µL/min.

This application note adopted the Full Evaporation Technique (FET) to analyze the solvent residual, based on California Residual Solvents Category, in cannabis oil.