Application Notes

-Overview of international guidances for data integrity -Insight into PIC/S guidances -Challenges of managing documentation

• Solutions for comparing innovator and biosimilar mAbs • Biosimilar case studies

• Data security in electronic versus paper environments • Division of responsibilities between users and vendors • Specific payment plans can provide advantages to meet financial goals.

-How to translate methods, maximize resolution, and comply with USP -Optimizing HPLC/UHPLC method development workflows -Column coupling can provide improved sample detail and high peak capacities

Automated QuEChERS clean-up of hemp oil extracts combined with liquid introduction and PTV-GC–MS determination of pesticides leads to improved throughput and low LOQs.

This application note adopted the Full Evaporation Technique (FET) to analyze the solvent residual, based on California Residual Solvents Category, in cannabis oil.

The ability to predict multiple constituents of a final dosage form in one fast, nondestructive measurement can reduce analysis time and cost significantly.

• Acquiring laboratory equipment raises a number of challenges and concerns. • Specific payment plans can provide advantages to meet financial goals.

- UHPLC-MS method for antibody analysis - Large-size protein separation at high temp

Multidimensional LC/MS is a powerful tool to gain info in the laboratory. Analyzing ADCs with multidimensional LC/MS provides fast data for CQAs.

· Traps and “delays” system-related PFAS, preventing interference · Allows accurate identification and quantitation of trace-level PFAS · Highly retentive-no breakthrough even with extended equilibration times

This work shows how thermal desorption with GC–MS is used to measure volatile organic biomarkers in the breath of individuals with malaria.

This work demonstrates the ability of the NexION® ICP-MS, coupled to the dedicated Syngistix™ Nano Application software module, to measure silver (Ag) nanoparticles in seawater and track their transformations over time.

EPA 8015C is a gas chromatographic method used to establish concentrations of a variety of non-halogenated volatile organic compounds, semivolatile organic compounds, and petroleum hydrocarbons. For the purpose of this application, a Clarus® 690 GC was used for the analysis of petroleum hydrocarbons, specifically Diesel Range Organics (DRO).

A sensitive, robust method for analysis of glyphosate in wide range of foods using a simplified sample preparation procedure effective for challenging matrices

Fast and sensitive HPLC method with post-column derivatization for analyzing Fumonisins in grains and feeds at levels as low as 0.01 ug/g

A sensitive method for testing of active compounds in cannabis and cannabis-containing products.

A solution for amino acids analysis, these methods were optimized to comply with system suitability requirements of Pharmacopoeia 8.0 methods.

Highly sensitive analysis of aflatoxins and ochratoxin A to guarantee the safety of hemp crop and hemp-containing consumer products.

An easy and sensitive method to analyze Aflatoxins B1, B2, G1, G2 and Ochratoxin A in cannabis plant and edible products at levels below established by state regulations.

A sensitive HPLC method allows analyzing cannabinoids, including THC and CBD, in hemp and hemp-containing products to ensure compliance with the 2018 Farm Bill.

This application note demonstrates the development of an SFC separation method for 46 highly polar compounds on different columns using an increased amount of modifier.

This technical overview presents the measurement of the instrument detection limit (IDL) at two different conditions of MRM dwell times.