Application Notes

μPAC™ technology has been used for analysing HCP impurities originating from recombinant expression systems used in the production of mAb based biotherapeutics.

Presented is a rapid, three step SPE procedure, that includes a concentration step, for the identification and quantification of fentanyl and its urinary analogs.

Outlines a simple three-step method for the extraction of Loperamide and its main metabolite, N-desmethyl Loperamide, from blood using Clean Screen® XCEL SPE|columns.

Presented is a rapid, three step SPE procedure, that includes a concentration step, for the identification and quantification of fentanyl and its urinary analogs.

UCT’s Refine™ Ultra-Filtration Technology allows for sample precipitation and filtration to occur simultaneously in the individual column or well.

This method outlines a modified QuEChERS based procedure that has been optimized to extract various drug compounds from liver prior to analysis by LC–MS.

UCT’s Refine™ Ultra-Filtration Technology allows for sample precipitation and filtration to occur simultaneously in the individual column or well.

Describes the highly retentive, universal nature of UCT’s polymeric Styre Screen® HLD sorbent for the analysis of acidic, neutral, and basic compounds in blood and urine.

This method outlines a modified QuEChERS based procedure that has been optimized to extract various drug compounds from liver prior to analysis by LC–MS.

Outlines a simple three-step method for the extraction of Loperamide and its main metabolite, N-desmethyl Loperamide, from blood using Clean Screen® XCEL SPE|columns.

This application describes an easy, fast, and effective method using QuEChERS for the quantitative analysis of benzodiazepines in whole blood.

This application describes an easy, fast, and effective method using QuEChERS for the quantitative analysis of benzodiazepines in whole blood.

With Antec Scientific’s new ground-breaking µ-PrepCell-SS, electrochemical reduction of disulfide bonds in peptides, proteins, mAbs, and other biopharmaceuticals becomes possible routinely in LC-MS workflows. • Fast and efficient reduction of S-S bonds • Robust on-line reduction in top-down and bottom-up Proteomics • Reagent free, no interfering DTT or TCEP, ideal for HDXMS • Superior peptide sequencing and S-S bond assignment

An effective enrichment method for glycopeptides were developed based on iSPE®-HILIC material. It opens a range of opportunities for glycoproteomics research.

Testing shows that Restek Long-Life ESI electrodes for Sciex Turbo V sources provide equivalent chromatographic performance to original equipment manufacturer electrodes over significantly longer lifetimes.

An efficient separation of polar and nonpolar lipid representatives was achieved utilizing iSPE®-HILIC material. The lipids were separated according to their polarity.

• Disaster recovery and business continuity plans are crucial for companies. • Most laboratories are not confident in their recovery and continuity plans. • When seeking solutions for system failures, consider regulatory guidelines.

The landscape for new biological drug development continues to evolve in complexity. With biosimilars entering the market and originator products coming off patent, the competitive race for market dominance is reliant on!

The landscape for new biological drug development continues to evolve in complexity. With biosimilars entering the market and originator products coming off patent, the competitive race for market dominance is reliant on!

This featured application note exploits the highly retentive, universal nature of UCT’s polymeric Styre Screen® HLD sorbent for the analysis of acidic, neutral, and basic compounds in blood and urine.

FDA recently posted an LC–HRMS method using the novel ACE3 C18-AR column, which can be used by regulators to detect “probable human carcinogen” NDMA in ranitidine.

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.

Note discusses how labs are coping with the worldwide helium shortage.

Determination of flavors in smoothies using standard- and solvent-swollen Twister® stir bars, liquid desorption, and LVI-GC/MS for enhanced recovery of polar compounds.

In this application we show how to achieve the best separation and sensitivity for insulin UHPLC-MS analysis by using formic acid as a weak ion pairing agent.

This application note demonstrates the ability of Daicel’s CHIRALPAK® IA-3 to perform both chiral and achiral separations using SFC and Hydrobenzoin as a test compound.