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Raffinose Family of Oligosaccharides Separated on a Hamilton HC-75
Identification and quantification of the Raffinose family of oligosaccharides allow a more thorough understanding of an individual’s gut health.
Determination of Adenine and Guanine Nucleotides in Tissue Extracts v2
The measurement of adenosine nucleotides represents important diagnostic measures concerning metabolic standing for the determination of various pathological states.
Separation of 12 Nucleosides on Hamilton PRP-1 Column v2
Modified nucleosides, either natural or synthetic, often provide RNA with distinctive properties useful in diagnostics or therapeutics.
Oligonucleotide Separation Using Reversed-Phase Ion Pairing Chromatography v2
Ion pairing agent aided separation of oligonucleotides from their potential failure sequences, highlighting the Hamilton family of reversed-phase HPLC columns.
Conquer Orbital Ion Trap Limitations
FcR Affinity Chromatography – A New Approach to Assess Glycan Profiles During Cell Line Screening and Upstream Development
App Note: Comprehensive Analysis of C2–C8 PFAS Using a Novel LC Column
Application Note: Promoter or Polluter? Separation of Triazines on HxSil C18 Column
Using the Empore™ C18 StageTips for High pH Peptide Fractionation in Global Proteomics
Simultaneous Low-level Quantitation of Four Impurities in Clozapine API using Triple Quadrupole LC-MS/MS
Sample Preparation Made Easy
Whether the application is wet, dry, or cryogenic, consistent and viable representation of sample preparation leads to more accurate and repeatable results for analysis.
Highly Sensitive LC-MS/MS Method for Simultaneous and Trace Level Quantification of Ten Nitrosamine Impurities in Olmesartan Medoxomil
N,N-DMF Selective and Highly Sensitive Quantification of NDMA and NDEA in Tetracycline Class Antibiotic Medication - A Case Study of Tigecycline
Highly Sensitive Quantification of Nitrosamines in Polymer-based Therapeutics-A Case Study of Sevelamer Hydrochloride 800mg Tablets
Extractables and Leachables: Future Outlook and Regulatory Implications
Summary of FDA Method C-010.01: Determination of PFAS in Food
This note summarises a procedure developed by the US Food and Drug Administration to measure 16 PFAS in food using a QuEChERS sample preparation approach and LC–MS/MS analysis.
Reversed Phase Flash Chromatography Purification of Peptide-Peptoid Hybrids
Purification of peptide-peptoid hybrids can be obtained by reversed phase chromatography with excellent recovery and resolution.
Improved Compound Recovery with ELSD Systems
The ability to collect compounds is directly related to the ability to detect them. Many compounds possess weak or non-existent chromophores which causes UV detection to exhibit poor yields.
The 2022 Resource Issue
Oligonucleotide Mapping Using BioPharma Finder Software
The development of comprehensive liquid chromatography–high resolution accurate mass workflows for confident identification and mapping of oligonucleotides.
Comprehensive Profiling of mAb Glycoforms Using the TSKgel® FcR-IIIA Affinity Columns: From Online Native Mass Spectrometry to Offline N-linked Glycans Analysis
Comparison of Denaturing RP-ESI-MS and Native SEC-ESI-MS for the Characterization of Monoclonal Antibodies
Reduced Metal Ion Introduction from Stainless Steel Processing Equipment via CVD Coatings
Identifying Pharmaceuticals in Wastewater Using Spectral and Mass Search: A Software Workflow
Is Chromatography Ready for the Cloud? Part 2
Activated Carbon PFAS Delay Column
PFAS are known to be persistent in the environment. Detecting low levels of PFAS in drinking water is made easier using an Activated Carbon Delay Column.
Analysis of Trace PFAS Vapours in Air
Sampling and analysis of a challenging range of trace-level volatile & semi-volatile vapours of per- & polyfluorinated alkyl substances (PFAS) in air using TD–GC–MS
Ion Pairing Reagents for Oligonucleotide Analysis
The effect of various ion pairing reagents (amines and acidic counterions) on the LC–UV and LC–MS analysis of oligonucleotides (ONs) has been studied.
Rapidly Identify Unknowns from Complex Samples
Use software to deconvolute LC–MS spectra from complex samples and identify unknown components.
App Note: Poisoned by Plastic, Analysis of BPA
Plasticizers added to water bottles to add stability to the bottles can be unknowingly extracted in drinks leading to possible endocrine interactions.
