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Characterization of Antibody-Drug Conjugates (ADC) using 2-Dimension Liquid Chromatography (2D-LC) and Native Mass Spectrometric Technologies
Ensuring Regulatory Compliance and Data Integrity with MassHunter Software Solutions
AN: Optimizing Control of Pump-Related Processes
This white paper will illustrate how integrated pump controllers optimize pump performance by automatically controlling flow or pressure.
Q-RAI Provides Rapid and Sensitive Data Independent Acquisition for Peptide Quantitation
Comprehensive Adeno-Associated Virus Critical Quality Attribute Analysis with Liquid Chromatography-Mass Spectrometry
Automated and simplified two Dimensional LC and High-Resolution MS approach for the identification and characterization of unknown impurity in Mirabegron tablets
Automated Dual Metabolite+Lipid Cell Sample Prep as a Component of an LC/HRMS-based Workflow to Elucidate the Molecular Response to Drug Treatment
Empore C18 StageTips for Peptide Fractionation
This app note demonstrates the application of Empore C18 StageTips to high pH peptide fractionation in global proteomics with enhanced peptide/protein identification.
PATfix™ pDNA analytics for in-process control of linear pDNA production
Application Note: Electrochemical Reduction of Biopharmaceuticals
With a new electrochemical cell, complete reduction of inter- and intra-disulfide bonds in mAbs is achieved. For cystine knots peptides, the sequence coverage was 100%.
Application Note: Hyaluronic acid Characterized by SEC-MALS-IV
The performance of hyaluronic acid is closely tied to its molar mass, intrinsic viscosity, and molecular conformation, quantified absolutely by multi-detector SEC.
Authentic or Synthetic? Discovering Authenticity Markers in Honey
Using sorptive extraction to extract aroma compounds from honey, with automated statistical analysis to uncover differences and determine markers of authenticity
Interview: Ultrapure Type 1 Water Guarantees Best Results for Reliable Analytical QC in the Beverage Industry
Suppressed Anion Chromatography – Analysis of Anions (SI-36 4D)
The SI-36 4D does not require organic solvent to achieve the separation. Gradient conditions and phosphate ions are eluted within 15 minutes, so analysis time is short.
Monovalent and Divalent Cations in Tap Water (Ethylenediamine EDA)
Monovalent and divalent cations in tap water were analyzed by IC YS-50.
Suppressed Anion Chromatography – Analyzing Oxyhalides and Anions (SI-52 4E)
Oxyhalides and anion standards in tap water were analyzed successfully using IC SI-52 4E. This is applicable to analyzing sources like rain, river water, and runoff.
Suppressed Anion Chromatography – Anion Standards (SI-90 4E)
The application successfully separates the 7 typical ions including F-, Cl-, NO2-, Br-, NO3-, PO43-, and SO42-, and it fulfills US EPA Method 300.1 (A) requirements.
Automated Analysis of 37 D/L-Amino Acids Using LC with Fluorescence Detection
This application introduces the automated analysis of fluorescent diastereomers of the proteinogenic D/L-amino acids using derivatizing reagents with chiral structures.
Anion Standards (Comparison of NI-424 and I-524A)
The seven main anions can be separated quickly using the IC NI-424 column. Improvement has been made in the separation of chloride and nitrite ions.
Rapid and High Resolution Fused-Core® Solutions for PFAS Analysis
Fused-Core® Technology benefits PFAS analysis for fast, efficient, and rugged separations which are paramount to environmental analysis.
PFAS Analysis Using Fused-Core® Technology
HALO® PFAS and PFAS Delay columns are application verified columns well suited for challenging environmental sample analysis.
PFAS Analysis of EPA 8327 v2
High resolution separation of 24 PFAS compounds using the HALO® PFAS Delay column coupled with the HALO® PFAS analytical column.
Rapid Analysis of 33 PFAS Compounds v2
High throughput analysis of 33 PFAS compounds found across EPA methods 533, 537.1, and 8327 in under 5 minutes.
HALO® PFAS Column Solutions v2
HALO® PFAS delay and HALO® PFAS analytical columns deliver rugged, reproducible performance for the most challenging environmental sample matrices.
Environmental Analysis of Harmful and Organic Chemical Compounds
Rapid and high-resolution analysis of PFAS compounds across EPA methods 537.1, 533, and 8327, using the new HALO® PFAS delay and analytical columns.
Recent Developments in Sample Preparation 2021
Application Note: Blood-Alcohol-Content Analysis Using Nitrogen Carrier Gas
Blood alcohol content is commonly analyzed in forensics; replacing helium carrier gas with nitrogen can provide the same quick, reliable, and accurate results.
Complementary Analysis with a 2D-LC–MS Instrument for Flexible Operation
This goal of this note is identity confirmation of protein-based impurities of a therapeutic protein by multi heart-cut 2D-LC–MS in a top-down experiment.
Application Note: Refining the Craft of Winemaking through Automated Analysis
King Estate Winery is one of the biggest and best producers in Oregon, U.S. Read about their success story of sustainable growth rooted in quality control.
Isolation of Paclitaxel
The fight against cancer employs many tools. Paclitaxel, a compound found in the bark of the Pacific yew tree, is one that that has been found to make a big difference.
