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MALDI-TOF Detection of Sulfonated Azo Colorants in Sweets and Candies
Shown here, is a simple, fast way to obtain qualitative information on the azo colorant content of confectionery products for their safe use in the food industry.
Introduction to Ion Chromatography Mass Spectrometry (IC-MS)
Learn how this powerful tool that can handle many challenging analytical tasks
Use of 2D-Liquid Chromatography in GMP Regulated Laboratories
Overcoming the Challenges of Liquid Chromatography Method Transfer: A CDMO Perspective
This case study demonstrates how method modernization is less difficult than the common perception, and good practices can be put in place to streamline the process.
Batch-to-Batch Comparison of Sub-2 µm Diol-Linked Size-Exclusion Columns (August 2022)
NIST mAb was analyzed using six different batches of 1.8 µm 200 Å dSEC-2 media packed with 150 mm length and 4.6 mm inner diameter columns.
Method Development for ADC Kadcyla by Size-Exclusion LC
Method development using standard phosphate containing buffers with different percentages of Isopropanol for aggregate analysis of an antibody-drug conjugate, Kadcyla.
What are Enzyme Assays Method Choices?
Learn more about enzyme assay, enzyme method, and choices. Are you seeking a better way to automate your enzyme analysis? This guide will help with your decision-making.
Heat and High pH Forced Degradation of Antibodies
The hydrophilic nature of the Biozen dSEC-2 stationary phase shows favorable aggregate profiles for forced degradation work under high salt conditions.
Improved Sensitivity and Recovery Using a Biozen dSEC-2 Column
Higher peak area for Biozen dSEC 2 column showing less adsorption occurring. Superior peak shape and recovery under USP mobile-phase conditions with Biozen dSEC 2 column.
Guard Column Lifetime and Capacity to Protect the Biozen dSEC-2 Column
Robustness of guard and attached analytical column evaluated for efficiency of trastuzumab biosimilar Kanjinti at suitable loading masses of bovine serum albumin.
White Paper: Size-Exclusion Chromatography (SEC) for the Determination of Protein Hydrodynamic Radius (August 2022)
Protein standards explored with known hydrodynamic radii, show how this can determine ideal size-exclusion conditions for optimal method performance using Biozen columns.
Screening Method for Identification of Forensic Drugs
This application note presents a fast HPTLC screening method for the identification of the most relevant forensic drugs.
Oligonucleotide Analysis by Size Exclusion Using a Biozen dSEC-2 Column
In this application note, we demonstrate the utility of size-exclusion chromatography (SEC) for the detection of high-order structure of single-stranded DNA oligonucleotides.
Improving Resolution for Size-Exclusion Chromatography Methods (August 2022)
Size-exclusion method improvements by running at a lower flow rate for the aggregate analysis of NIST mAb using a Biozen dSEC-2 column
Size-Exclusion Analysis Following IdeS Digestion Using a Biozen dSEC-2 Column
This technical note demonstrates the characterization of subunits for three monoclonal antibodies, post digestion with IdeS, using the Biozen dSEC-2 size-exclusion column.
Speed Up Multiresidue Pesticides Analysis in Food with Low-Pressure GC–MS
This LPGC–MS pesticides analysis utilizes a low-pressure GC column kit, comprised of a narrow restrictor column, factory coupled to a wider Rtx-5ms analytical column.
Automated Extraction of Benzodiazepines from Urine
Benzodiazepines are depressants and used to relieve anxiety, insomnia, and more. This app note discusses a urine extraction to confirm the presence of benzodiazepines.
SPE of Opioids from Blood and Urine
A simple and robust method for the analysis of Opioids in biological matrices using UCT's Clean Screen® DAU SPE column and Selectra® DA UHPLC column.
Isoflavones and Mycotoxins in Soy Beans (August 2022)
Analyzing crops for beneficial and harmful compounds is an indispensable tool for assessing the viability of various agricultural crops for consumption.
LGC Pharmaceutical Nitrosamines
Thermal Extraction of VOCs Using a Multi-ramp Method
This application note demonstrates a quick temperature ramp technique to improve the focusing of VOCs without a need for trapping.
Improved Separation Performance of mAbs and ADCs
This application note discusses SEC and how to reduce undesired secondary interactions between proteins and the LC column hardware.
Expanding SEC Platform Method Versatility for mAb Analysis
This application note reviews use a of new SEC column technology to streamline method development for reliable size-variant analysis of therapeutic proteins.
A New Benchmark in Inert SEC Column Design
This application note discusses synergistic coupling of new SEC particle and hardware technologies to reduce non-desired secondary interactions in protein SEC analyses.
Characterizing Vaccines with Light Scattering (August 2022)
Light scattering methods inform on essential properties and attributes of vaccines including size, aggregation, stability, interactions, composition, and conformation.
USP Monograph mAb SEC Method Robustness on SEC Column
This application note discusses the advantages of using Waters XBridge™ Premier Protein SEC column in the published USP monograph for SEC-based mAb analyses.
Advantages of integrated Ultraviolet/Visible (UV/Vis) spectral processing for LC
Highly Sensitive, Selective LC–MS Instrument for Cleaning Validation
This application shows a highly sensitive and selective quantitative analysis for macrolides with poor UV absorbance using single-quad LC–MS.
LC–MS Analysis of Organic EL Materials and Impurities
This article describes an example of using single quad LC–MS to check the synthesis of organic EL materials and predict the molecular weights of impurities they contain.
LC–MS Analysis of Impurities in Montelukast
Report shows how using LC–MS as part of an analysis makes it easy to obtain molecular weight information of APIs for easy peak identification.
