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Fast Determination of the Bitter and Clove-Like Flavour in Beer with the Agilent 1290 Infinity II LC
May 24th 2016In this application the Agilent 1290 Infinity II LC was used to determine the bitter compounds iso-alpha-acids and reduced iso-alpha-acids, and the clove-like phenolic flavor 4-vinylguaiacol in bottled beer.
Fast Determination of the Bitter and Clove-Like Flavor in Beer with the Agilent 1290 Infinity II LC
May 24th 2016In this application the Agilent 1290 Infinity II LC was used to determine the bitter compounds iso-alpha-acids and reduced iso-alpha-acids, and the clove-like phenolic flavor 4-vinylguaiacol in bottled beer.
Estradiol Extraction From Serum Using SLE+
May 20th 2016This application note describes the use of ISOLUTE SLE+ for extraction of estrone (E1) and estradiol (E2) from human serum. Analysis is performed by an HPLC-MS/MS method that gives limits of detection of 0.001 ng/mL without derivatization or fluoride adduct stabilization. ISOLUTE SLE+ products provides high analyte recoveries, no emulsion formation and significantly reduced sample preparation time compared to traditional liquid-liquid extraction.
Separation of Methyclothiazide Using CHIRALPAK IG
May 17th 2016A CHIRALPAK IG column (immobilized meta selector) was used to develop the enantioselective separation of methylclothiazide. Meta-substituted immobilized chiral selectors have been shown to have remarkable affinity for resolution of chiral compounds from different types of molecules.
HPLC to UHPLC Transfer of USP Method for Amlodipine Besylate
This Application Note describes the method transfer of a USP HPLC method for amlodipine besylate tablets to a UHPLC method using the Agilent 1290 Infinity II LC.
HPLC to UHPLC Transfer of USP Method for Amlodipine Besylate
This Application Note describes the method transfer of a USP HPLC method for amlodipine besylate tablets to a UHPLC method using the Agilent 1290 Infinity II LC.
Determination of 11-nor-9-Carboxy-THC in Human Urine by QuEChERS and LC-MS/MS
April 25th 201611-nor-9-Carboxy-THC, also known as THCA or carboxy-THC, is the main secondary metabolite of THC (the active component of marijuana) formed in the human body [1]. THCA is excreted in urine in the form of glucuronide conjugates. THCA is not psychoactive but has a long half-life of up to several days or even weeks in very heavy users, thus determination of THCA in urine plays an important role in confirmation of marijuana consumption. The Substance Abuse and Mental Health Services Administration (SAMHSA) has set the THCA cutoff concentration of confirmatory testing at 15 ng/mL. Typical sample preparation methods for THCA in urine include liquid-liquid extraction (LLE) and solid phase extraction (SPE). This application utilizes a novel sample preparation technique, QuEChERS to effectively quantitate THCA levels in human urine.
Automated Extraction and Analysis of Isomeric Cortisone and Prednisolone
April 16th 2016A simple automated extraction method using a Tecan Freedom EVO® 100 liquid handler and Phenomenex’s Novum simplified liquid extraction (SLE) 96-well plate. Analysis of isomeric cortisone and prednisolone by UHPLC by Kinetex 2.6 μm, 50 x 3 mm core-shell Biphenyl column was used to successfully separate these two compounds and their isomers.
Automated Extraction and Analysis of Isomeric Cortisone and Prednisolone
April 16th 2016A simple automated extraction method using a Tecan Freedom EVO® 100 liquid handler and Phenomenex’s Novum simplified liquid extraction (SLE) 96-well plate. Analysis of isomeric cortisone and prednisolone by UHPLC by Kinetex 2.6 μm, 50 x 3 mm core-shell Biphenyl column was used to successfully separate these two compounds and their isomers.