Application Notes: LC-MS

This application note provides an optimised and validated fully automated sample preparation and LC–MS/MS analysis solution for seven target nitrosamines in two classes of drug substance.

A highly sensitive, validated method for atrazine determination in different water types using the QSight 420 LC–MS/MS employed a simple filtration and direct injection.

Using the LX50 UHPLC and QSight 420 triple quad MS, three analytical methods were developed to provide sensitive, reproducible results without the need for pre-concentration steps.

This work is focused on the development of a novel SARS-CoV-2 spike glycoprotein assay based on BAMS™ assay platform with detection by MALDI-TOF MS.

A methodology for a sensitive and repeatable analysis of PPCPs in drinking water utilizing the QSight SP50 Online SPE system coupled to a QSight 220 MS/MS.

Reveal more veterinary drugs in Food. Use the QSight LC–MS/MS to get a fast, selective, and sensitive method for the determination of sulfonamide antibiotics in milk.

HALO® PFAS delay and HALO® PFAS analytical columns deliver rugged, reproducible performance for the most challenging environmental sample matrices.

To improve the chromatography of PFAS and other environmentally concerning chemicals, application-assured HPLC columns have been developed to deliver high efficiency and robust analysis.

This application demonstrates the capability of the HALO® PFAS columns for separating branched and linear isomers of PFAS species PFHxS, found in well water.

High throughput analysis of 33 PFAS compounds found across EPA methods 533, 537.1, and 8327 in under 5 minutes.

High resolution separation of 24 PFAS compounds using the HALO® PFAS Delay column coupled with the HALO® PFAS analytical column.

Rapid and high-resolution analysis of PFAS compounds across EPA methods 537.1, 533, and 8327, using the new HALO® PFAS delay and analytical columns.

To improve the chromatography of PFAS and other environmentally concerning chemicals, application-assured HPLC columns deliver high efficiency and robust analysis.

In this application note high resolution SCX was coupled directly to an ultrasensitive online native MS using YMC’s BioPro IEX SF to analyse mAb charge variants.

This note demonstrates a novel, easy-to-use, intelligent tandem nanoLC-MS setup capable of 100% MS use that is compatible with the Sonation double-barrel nano ESI source.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Analysis of GHB demands for an analytical procedure that is quick, efficient, and one that preserves the authenticity of the sample. A method for the quantitation of GHB in human blood is presented using SPE with LC-MS/MS analysis.

A fast and efficient SPE sorbent, Strata-X PRO, was chosen to extract a panel of acids, neutrals, and bases from plasma to reduce the number of steps in the clean-up.

This application focuses on developing a rapid SPE and LC-MS/MS method for the quantitative analysis of uracil and its two homologues from human serum.

In this application, an SPE method is implemented for a panel of pain relievers to produce acceptable results to offer an alternative solution for high recoveries and to reduce matrix effects.

In this panel of veterninary drugs from a milk sample, SPE displays an improved solution over traditional protein precipitation methods and other types of SPE, due to clean up efficiency, all while maintaining a rapid and fast analysis time.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Introducing 3 unique particle platforms for SPE that offer additional cleanliness, recovery and accuracy for industry specific applications. Each mini application guide displays an application for each type of SPE solution.

Efficient and reproducible separation of thymidine oligomers is achieved using an ion-pair reversed phase shallow gradient method with the Avantor® ACE® Oligo column.

This application demonstrates the efficacy of this chromatographic technique for a fast orthogonal analysis to evaluate mAb ADCC activity.

Our compilation of Avantor® ACE® applications for key analyte classes in cannabis products and potential contaminants provides technical support for this key expanding area.

The TSKgel UP-SW Aggregate 30 nm column demonstrates the advantages of using a larger pore size when analyzing high-order aggregates and large molecules.