Application Notes: LC-MS

Learn how to simplify the connectivity from your µPAC™ column to your mass spectrometer, with Nanospray Flex source. Only two connections, from column to emitter.

The µPAC™ GEN2 nanoLC columns are specifically designed to further improve your LC–MS results. More IDs and higher reproducibility for more confidence in your data.

The µPAC™ Limited Sample Amount column is designed for ultrahigh sensitive separation performance for the smallest sample amounts, typically less than 20 ng of content.

Learn about the µPAC™ trapping columns, and see how they can help sample preconcentration in nanoLC–MS. Pick your preferred workflow, forward or backflush, and run.

Fortis Technologies has launched a new application note on the analysis of cannabinoids. A sample of twelve cannabinoids was analyzed by LC–MS in 7 minutes.  

Estrone, beta-estradiol, and estriol were derivatized from plasma using Novum PRO 96-Well Plates SLE to provide less background noise.

In this application, serum was cleaned up and compared with both a single protein precipitation protocol and also by the addition of a phospholipid removal product.

Miniaturized LC–MS and SPE method for the reliable and accurate detection of viral pesticides at 1 fmol/uL using SARS-CoV-2 nucleocapsid protein as a model system.

A quantitative LC–MS/MS method using a room-temperature hydrolysis with an advanced SPE product for the analysis of designer and pharmaceutical benzodiazepines in urine

An in-well hydrolysis solid-phase extraction (SPE) product is used for an easy clean-up solution for the urine sample matrix to save time and transfer steps.

Testosterone was isolated from plasma using Novum PRO 96-well plates SLE sample preparation.

An SLE media provides a fast sample prep method. Adding advanced manufacturing processes leads to high recoveries and low variation between samples.

In this application, serum was cleaned up and compared with both a single protein precipitation protocol and also by the addition of a phospholipid removal product.

The unique design of the 50 cm μPAC™ GEN2 nanoLC column provides superior performance over state-of-the-art packed bed columns, achieving peak capacities of over 1000.

Here we present a mycotoxin screening method for beer grain and beer samples utilizing a HALO PFP column, which enables high sensitivity, high resolution, and high-speed separations for this analysis.

Nitrosamines are potentially dangerous genotoxic compounds that have been recently found within some pharmaceutical products. We demonstrate highly sensitive methods to accurately detect and quantify these compounds.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC–MS/MS for measuring pesticides in spinach purchased from local grocers is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in honey purchased from local apiaries is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in kale purchased from local grocers is described in this application note.

A SLE application for acids (THC-COOH), neutrals (barbiturates), and bases (Norbuprenorphine and Buprenorphine) from a urine matrix containing β-glucuronidase followed by two LC-MS/MS methods.

Estrone, beta-estradiol, and estriol were derivatized from plasma using Novum PRO 96-Well Plates SLE for less background noise and cleaner samples post sample preparation.

This application focuses on developing a rapid SPE and LC-MS/MS method for the quantitative analysis of uracil and its two homologues from human serum

Testosterone was isolated from plasma using Novum PRO 96-Well Plates SLE sample preparation.

Analysis of GHB demands for an analytical procedure that is quick, efficient, and one that preserves the authenticity of the sample. A method for the quantitation of GHB in human blood is presented using SPE with LC-MS/MS analysis.

In this application, an SPE method is implemented for a panel of pain relievers to produce acceptable results to offer an alternative solution for high recoveries and to reduce matrix effects.

A sensitive method for analyzing nicotine and metabolites using SLE to increase recoveries, while still displaying accuracy, precision and linearity.

In this panel of veterninary drugs from a milk sample, SPE displays an improved solution over traditional protein precipitation methods and other types of SPE, due to clean up efficiency, all while maintaining a rapid and fast analysis time.

Peptides are extracted from plasma comparing Strata-X PRO SPE to two types of ion exchange polymeric sorbent. Strata-X PRO provides high recoveries with a fast and effective clean-up method.

Revolutionize your bioanalytical sample preparation. Search application notes by your compounds of interest, application area, SOLA chemistry phases, or SOLA formats.

Simplify coupling the µPAC™ column to the emitter. Only 2 connections, an integrated liquid junction and grounding point for robust, low dispersion nanoLCMS interfacing.