Application Notes: LC-MS

A municipal wastewater laboratory demonstrates the use of QuEChERs sample preparation techniques to analyze PFAS in sediments at sub ng/g levels.

A wide variety of LC column chemistries were evaluated to demonstrate new chromatographic approaches to complex PFAS analyte lists.

Strata-SDB-L and Luna Omega 1.6 µm PS C18 demonstrate excellent precision and recovery in EPA Method 537.1 for the analysis of PFAS in drinking water.

A novel LC approach to manipulate the chromatography of closely related PFAS analytes to separate co-eluties and avoid matrix interferences.

This application note demonstrates robust and sensitive quantitation of 10 nitrosamines, and the use of the LC–SRM–MS to quantify nitrosamine impurities in metformin.

This application note demonstrates fast, highly sensitive quantitation of nine nitrosamines, and the use of the LC–MS method to measure nitrosamine.

PFAS are an emerging concern to environmental health. This has driven the need to monitor and calls for global regulations to restrict or eliminate them.

See how the µPAC™ capLC LC–MS column can help increase sample throughput, and at the same time maintain the highest separation efficiency and sensitivity.

See how the µPAC™ capLC LC–MS columns can contribute in the characterization of the glycosylation pattern of therapeutic enzymes.

Learn how to simplify the connectivity from your µPAC™ column to your mass spectrometer, with Nanospray Flex source. Only two connections, from column to emitter.

The µPAC™ GEN2 nanoLC columns are specifically designed to further improve your LC–MS results. More IDs and higher reproducibility for more confidence in your data.

The µPAC™ Limited Sample Amount column is designed for ultrahigh sensitive separation performance for the smallest sample amounts, typically less than 20 ng of content.

Learn about the µPAC™ trapping columns, and see how they can help sample preconcentration in nanoLC–MS. Pick your preferred workflow, forward or backflush, and run.

Fortis Technologies has launched a new application note on the analysis of cannabinoids. A sample of twelve cannabinoids was analyzed by LC–MS in 7 minutes.  

Estrone, beta-estradiol, and estriol were derivatized from plasma using Novum PRO 96-Well Plates SLE to provide less background noise.

In this application, serum was cleaned up and compared with both a single protein precipitation protocol and also by the addition of a phospholipid removal product.

Miniaturized LC–MS and SPE method for the reliable and accurate detection of viral pesticides at 1 fmol/uL using SARS-CoV-2 nucleocapsid protein as a model system.

A quantitative LC–MS/MS method using a room-temperature hydrolysis with an advanced SPE product for the analysis of designer and pharmaceutical benzodiazepines in urine

An in-well hydrolysis solid-phase extraction (SPE) product is used for an easy clean-up solution for the urine sample matrix to save time and transfer steps.

Testosterone was isolated from plasma using Novum PRO 96-well plates SLE sample preparation.

An SLE media provides a fast sample prep method. Adding advanced manufacturing processes leads to high recoveries and low variation between samples.

In this application, serum was cleaned up and compared with both a single protein precipitation protocol and also by the addition of a phospholipid removal product.

The unique design of the 50 cm μPAC™ GEN2 nanoLC column provides superior performance over state-of-the-art packed bed columns, achieving peak capacities of over 1000.

Here we present a mycotoxin screening method for beer grain and beer samples utilizing a HALO PFP column, which enables high sensitivity, high resolution, and high-speed separations for this analysis.

Nitrosamines are potentially dangerous genotoxic compounds that have been recently found within some pharmaceutical products. We demonstrate highly sensitive methods to accurately detect and quantify these compounds.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC–MS/MS for measuring pesticides in spinach purchased from local grocers is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in honey purchased from local apiaries is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in kale purchased from local grocers is described in this application note.

A SLE application for acids (THC-COOH), neutrals (barbiturates), and bases (Norbuprenorphine and Buprenorphine) from a urine matrix containing β-glucuronidase followed by two LC-MS/MS methods.