Gas Chromatography (GC)

For trace quantitative analysis, the splitless technique is most used as an inlet capable of performing both split and splitless injections. In this and upcoming installments, we take a closer look at splitless injection.

The introduction of comprehensive two-dimensional gas chromatography (GC×GC) to the sample screening toolbox has substantially increased the ability to comprehensively characterize complex mixtures. However, for many gas chromatography (GC) users, the thought of having to learn to develop methods on a new technology is daunting. Developing a basic GC×GC method for most (nonspecialized) applications can be accomplished in minimal time and effort given parameter suggestions and ranges to target analytes in a sample of interest. In this article, the authors work describe a simple workflow to develop a GC×GC method for a specific sample upon initial use, with the aim of decreasing the time to accomplish functional workflows for new users.

Column insertion distance is critical to good chromatography. What happens if the column is installed too low in the injection port? Is insertion distance more important when performing split injection or splitless injection? Does the position of the column in the injection port impact reproducibility?

University of Bonn scientists monitored how column properties can affect the dynamics between characteristic and elution temperatures in gas chromatography (GC).

In this LCGC Blog, Daipayan Roy and Muhammed Qamar Farooq of Amgen discuss the history and impact of supercritical fluid chromatography (SFC) throughout the years.

Here are the top five articles published on LCGC International this week.

A recent study analyzed nearly 100 CBD products to test the accuracy of advertised cannabinoid content.

Scientists from Shanghai Jiao Tong University and the Sichuan China Tobacco Industry Company used gas chromatography-ion mobility spectrometry (GC-IMS) to analyze the flavor profiles of different cigars.

Scientists from the Federal University of Santa Catarina reviewed recent advancements made in the chromatographic analysis of endocannabinoids and phytocannabinoids in biological samples.

Here are the top five articles published on LCGC International this week.

Connecticut Agricultural Experiment Station scientists recently used gas chromatography with flame ionization detection (GC-FID) to measure different components in cannabis hemp samples.

University of Messina scientists recently used GC-based techniques to help characterize essential oil from Piper gaudichaudianum Kunth, a plant native to Brazil.

In this article, we discuss the fundamentals of headspace extraction, including static versus dynamic extraction, establishing equilibrium in the vial, consequences of the partition coefficient, temperature, pressure, and transfer to the gas chromatograph.

Pharmaceutical excipients, such as polyethylene glycol-based polymers, must be tested for the presence of ethylene oxide (EtO) and 1,4-dioxane as part of a safety assessment, according to USP Chapter <228>.

Mankind Research Centre scientists recently tested a new solid phase extraction (SPE)-based approach coupled with GC–MS for analyzing small molecule N–nitrosamine impurities in antitussive syrups.

São Paolo State University scientists recently used pyrolysis gas-chromatography–mass spectrometry and dispersive liquid-liquid microextraction to determine flame retardants in sewage.

Here are the top five articles published on LCGC International this week.

University of Campinas and Iowa State University scientists recently combined vacuum-assisted sorbent extraction (VASE) and gas chromatography-mass spectrometry (GC–MS) to determine polycyclic aromatic hydrocarbons in açaí-based food products.

University of Washington scientists used comprehensive two-dimensional (2D) gas chromatography (GC×GC) paired with time-of-flight mass spectrometry (TOFMS) to study moisture-damaged cacao beans.

Here are the top five articles published on LCGC International this week.

Chinese Academy of Inspection and Quarantine scientists recently used gas chromatography–tandem mass spectrometry (GC–MS/MS) to create a new detection method for screening hazardous substances in teethers.

The 2024 HPLC conference in Denver, Colorado will include several awards presentations including the Uwe D. Neue Award in Separation Science and the Chromatography Society Jubilee Medal.

Here are the top five articles that the editors of LCGC International published this week.

Shaanxi University of Technology scientists recently used analytical techniques including gas chromatography to identify various volatile organic compounds (VOCs) in different types of Chinese bacon.

Separation scientists frequently encounter critical pairs that are difficult to separate in a complex mixture. To save time and expensive solvents, an effective alternative to conventional screening protocols or mathematical peak width reduction is called iterative curve fitting.

Scientists from the University of Turin, Italy have learned how to combine their complementary competencies in analytical chemistry and big data analytics to achieve significant advances in food science and health.

Webinar Date/Time: Wed, Aug 7, 2024 11:00 AM EDT

University of Helsinki scientists have created a new simplified method of ion mobility spectrometry.

In this edition of the LCGC Blog, Amber Hupp of the College of the Holy Cross provides advice for aspiring analytical chemists and shares accounts of other professionals.