Podcasts

Introducing a new dimension in separations! The new HALO® 1.5 mm ID UHPLC columns from Advanced Materials Technology push the performance of UHPLC systems by delivering more sensitivity and 50% less solvent consumption than contemporary 2.1 mm ID columns. Additional benefits of moving to the new, robust 1.5 mm ID columns will be discussed including the ease of implementation commercial UHPLC instrumentation.

Per- and polyfluoroalkyl substances (PFAS) are of increasing concern. In October 2021, the U.S. Environmental Protection Agency (EPA) announced an action plan for addressing PFAS, including establishing maximum contaminant levels for drinking water. The vast presence and detrimental impact to human health and the environment of these analytically challenging compounds has led to focus on technique rigor necessary for sensitive, reproduceable and reliable data. In this podcast, Senior Application Scientist, Jamie Foss, addresses the differences between EPA methods 533 and 537.1, and how to overcome key LC-MS/MS technique challenges when performing analysis in accordance with these methods.

Keeping your instrument at peak performance levels is the best way to prevent loss of productivity due to unscheduled downtime. Proactive replacement of certain instrument components, tailoring instrument service to meet your specific lab’s needs and upgrading your instruments with the latest technology is the best way to cost-effectively manage your laboratory’s assets. Waters offers flexible service plans to help with the challenges of costly unplanned downtime.

Do you struggle with sample preparation? You are not alone! Sample preparation is often labeled as the no. 1 pain for scientists around the world. Scientists try to reduce this pain by settling for a sample preparation method or product that is less than ideal, causing even more pain further down the road. But imagine if you could eliminate some of that pain by simply choosing the right sample preparation product? In this podcast, we will help dissolve the myth that sample preparation pain is unavoidable by equipping you with proper selection recommendations and tips and tricks based on what matters to you most.

In the highly competitive beverage market, rapid and flexible processes and systems are vital for ensuring products meet the demands of the sector. As such, beverage processors must utilize portable, quick and intuitive testing solutions to ensure the production of high-quality beverages.

Filtering analytical samples and mobile phase solutions using the correct filtration device is an economical way to reduce instrument downtime, maintenance, and associated costs. Ensuing samples are free from particulate contamination will ensure the integrity of your instrument and columns, offering you more reliable and reproducible results. In this podcast you will learn more about the considerations that should be made when selecting the best analytical filtration device.

The latest Dr. Ehrenstorfer podcast sees LGC expert Dan Biggerstaff discuss the ever evolving topic of nitrosamines. Sharing his expertise, you'll learn about the complex but important topic of nitrosamine regulation, the challenges laboratories face when testing for nitrosamines and how to overcome these.

Finally, something that works! Find out how to get great testing results when quantifying cannabinoids in edibles. In this podcast, we will share simple extraction procedures to generate cleaner samples with the very best accuracy. If you are tired of clogging your LC columns and getting strange results, this podcast is for you.

In the final episode of this six-part podcast, Robert Moritz, a professor at the Institute for Systems Biology, discusses major challenges that still exist with liquid chromatography and mass spectrometry, liquid chromatography’s role in LC-MS proteomics, and where this field is headed in the next few years and beyond.

In the fifth episode of this six-part series, Bogdan Budnik, principal scientist at Harvard Center for Mass Spectrometry, discusses common challenges related to nano LCMS proteomics analysis of very diverse sample types, improvements in proteomics analysis, and how single-cell proteomics will impact the medical field.

Polymers for life-science applications have different attributes from traditional applications such as automotive and packaging. These attributes have their own set of challenges in the characterization requirements of such complex molecules. Multi-angle light scattering (MALS) technology provides a more insightful tool.

Aimed at GMP-regulated laboratories, this podcast discusses the regulatory and business drivers for digitizing analytical processes, how they go hand in hand, and some practical aspects on how to approach such a journey. The business benefits of improving laboratory efficiency by releasing product earlier, and technical controls to ensure regulatory compliance, should easily justify automation projects. It is crucial to automate now under your own timeline rather than be forced by regulatory citations.

Poor quality data can negatively impact a lab’s reputation and its bottom line. Jodi McDonald, President of Keystone Labs, applied her pharmaceutical GMP learnings to the challenges of cannabis testing. Gain from her experience as she shares tips to ensure the quality of cannabis from sample collection to analysis.

In the fourth episode of this six-part podcast, David Perlman, senior principal scientist and director of ultrasensitive proteomics at the Merck Exploratory Sciences Center, discusses where LC-MS proteomics has the largest impact, the need for single-cell proteomics, the promise single cells have on our day-to-day lives, and more.

In episode 3 of this six-part series, Karl Mechtler, head of the protein chemistry facility at the Research Institute of Molecular Pathology, Vienna, Austria, discusses the critical role of nano LC separation performance for reproducible and quantitative deep-dive proteomics analysis.

This episode will cover the progress towards a new AOAC method for metals in cannabis and the efforts taken toward reaching this goal. Helpful information for all cannabis labs interested in running metals will be shared, including our latest and greatest, ICP-MS Cannabis Analyzer and how it should be a player in your lab!

Biomolecules such as proteins, antibodies or viral vectors are becoming increasingly important therapeutics, as evidenced by clinical trials and ultimately drug approvals. But they are also significantly different from small molecules, which affects their HPLC analysis. We explain the differences and what that means for the HPLC conditions and modes used to analyze biomolecules.

Potency testing in cannabis, hemp, and cannabinoid products is required in every region where the use and production of these products is permitted by law. Although ostensibly a simple HPLC testing method, it can be fraught with potential pitfalls. These include poor extraction efficiency, poor methodology, and outcome bias from lab to lab. In this episode, we will examine these issues and discuss the utility of mass spectrometry as an alternative to address the shortcomings of HPLC.

Alexander Boychenko, Product Marketing Manager at Thermo Fisher Scientific focused on low-flow LC technologies provides insights into the benefits of the state-of-the-art nano-, capillary- and micro-flow UHPLC system hyphenation with MS.

The need for enhanced product quality of biomolecules has led to a higher-level of characterization of different critical quality attributes. Size exclusion chromatography (SEC) has been widely used as a technique to provide size and purity. SEC coupled with multi-angle light scattering (MALS) can determine molecular weight (MW) and size (or radius of gyration, Rg) of complex samples. Dr. Wei Lu, Ph.D. and Philip Hoang from Tosoh Bioscience discuss how SEC-MALS as an analytical method can be optimized and applied to a wide range of applications including oligonucleotides, monoclonal antibodies, and virus-like particles.

This podcast will examine peak deconvolution with photodiode array detectors and how a unique software function can separate peaks that are not resolved on-column, yielding better detection results and minimizing method development and analysis time. The podcast will explore the development of this tool with a leading pharmaceutical company and provide examples of how it can have an impact across a wide range of disciplines in the pharma/biopharma arena, from development to production.

Recent life science technologies incorporate polymers and biopolymers as key component of their drug products. Polymers play essential roles in controlled drug elution as well as target drug delivery, therefore advanced analytical solutions are required to properly assess the safety and efficacy of these new life science technologies. Join-us to learn more about the advanced analytical solutions for life science technologies.

Go beyond the hype of digital transformation and learn its true promise. With advanced analytics in your pharma labs, you can transform all your data into actionable scientific and business insights that lead to better outcomes. LabVantage Solutions is working with pharmaceutical companies worldwide to integrate their labs with their enterprise digital ecosystems. Find out how LabVantage’s informatics platform, complete with AI-powered, self-service analytics, is making a difference across the pharmaceutical industry.

Ionization Labs, through their Cann-ID potency testing solution has opened up market access to high level chemical analysis tools that have historically been available only to highly trained users. Hear from the Ionization Labs Co- Founders on what sets their solution Cann-ID apart and why every cannabis / hemp operation should be utilizing it.