Large-Volume Injection LC–MS-MS Methods for Aqueous Samples and Organic Extracts
May 1st 2015Environmental sample analysis by large-volume injection (LVI) in combination with liquid chromatography–tandem mass spectrometry (LC–MS-MS) is described for polar and nonpolar analytes in both aqueous samples and organic extracts.
Event News: 31st Montreux Symposium on LC–MS and MS–MS
May 1st 2015The 31st Montreux Symposium on LC–MS and MS–MS will be hosted by the International Association of Environmental Analytical Chemistry (IAEAC) at the Aldershof Convention & Exhibition Centre, Berlin?Aldershof, Germany, on 4–6 November 2015.
Simultaneous Determination of Methotrexate and Sulphasalazine in Plasma by HPLC–DAD
May 1st 2015Here we describe a simple and robust high performance liquid chromatography–diode array detection (HPLC–DAD) method for the simultaneous determination of methotrexate (MTX) and sulphasalazine (SSZ) from plasma. MTX and SSZ are used in combination for the treatment of rheumatoid arthritis. Using two detector wavelengths, 304 nm for MTX and 358 nm for SSZ, we were able to selectively quantitate both analytes during the same chromatographic run. The method was validated using quality control samples for critical analytical performance criteria of recovery, reproducibility, selectivity, accuracy, and precision.
A New Era for Lab-on-a-Chip Technologies?
April 24th 2015Miniaturization has been one of the biggest trends in recent years. This article discusses the evolution and current applications of lab?on-a-chip technology in chromatography and explores the possibility of a new market for microfluidics in separation science.