Kelly Zhang

In the pharmaceutical industry, the use of mass spectrometry in high-throughput experimentation (HTE) has increased, thanks to the technique’s speed, sensitivity, and selectivity. We systematically evaluate the applicability of multiple MS techniques for different types of HTE samples and purposes, reviewing the pros and cons, and provide practical recommendations, Illustrated by application case studies.

Material identification is a common need in many industries, most notably for pharmaceutical manufacturing where the United States Pharmacopeial Convention (USP) defines many identification tests.

A method is described that incorporates a mobile-phase gradient consistent with a HILIC separation mechanism and uses a mixed-mode column, which provides reversed-phase and cation-and anion-exchange properties, and charged aerosol detection.