Author
Latest:
Pesticide and Mycotoxin Analysis: Mastering the Complexity of the Cannabis MatrixResearch scientists in the cannabis field are tasked with validating robust methods that can be seamlessly transitioned into production laboratories. Unlike typical disciplines where controls are easily (and legally) obtained through known manufacturers, analytical chemists working for both consumable vendors as well as cannabis laboratories must do their best to develop methods often without such resources at their disposal. As the industry matures and additional regulations are adopted, the evolution of the pesticide testing subsection continues to be vastly different depending on the jurisdiction one does business in. This creates an interesting challenge for commercial scientists tasked with developing methods that will appeal to a majority of their consumers, while also generating unexpected hurdles to said laboratories once the methods are placed into production. Ace Analytical Laboratory, located in Las Vegas, Nevada, has successfully adopted and validated pesticide testing methods for their cannabis laboratories and has gained valuable insight into how to best work with such a difficult matrix. In conjunction with UCT, LLC, an overview of best practices and method development techniques for pesticide testing in cannabis is discussed below and told from a technical perspective.
Latest:
Analysis of Organic Compounds in Water Using Unique Concentration–Injection Techniques for Portable GC–MSIn this study, a simple method was used for extraction and concentration of trace organic compounds in water, followed by injection using a coiled wire filament and GC–MS analysis. Common semivolatile organic compound contaminants at low parts-per-billion levels were detected in less than 10 min.
Latest:
Analysis of Organic Compounds in Water Using Unique Concentration–Injection Techniques for Portable GC–MSIn this study, a simple method was used for extraction and concentration of trace organic compounds in water, followed by injection using a coiled wire filament and GC–MS analysis. Common semivolatile organic compound contaminants at low parts-per-billion levels were detected in less than 10 min.
Latest:
Testing the Limits of Ion Mobility Mass Spectrometry to Compare a Nonbiological Complex Drug Product and Purported Generics—A Case Study with CopaxoneThe analysis of oil samples containing many thousands of constituents best illustrates the benefits of ion mobility MS for complex samples. Here, we test the limits of ion mobility MS to discern differences between batches of Copaxone, a highly complex drug containing billions of peptides, and various purported generic versions of the drug.
Latest:
The Application of Computational Chemistry to Problems in Mass SpectrometryWith computational chemistry, chemists can now study chemical phenomena by performing computationally intense calculations on computers rather than examining reactions and compounds experimentally. This is especially attractive when the laboratory experiments are time consuming, costly, dangerous, or difficult. Modern computational chemistry tools are capable of determining molecular structures, molecular spectra, and energetics, and of elucidating reaction pathways and chemical reaction products.
Latest:
Testing the Limits of Ion Mobility Mass Spectrometry to Compare a Nonbiological Complex Drug Product and Purported Generics—A Case Study with CopaxoneThe analysis of oil samples containing many thousands of constituents best illustrates the benefits of ion mobility MS for complex samples. Here, we test the limits of ion mobility MS to discern differences between batches of Copaxone, a highly complex drug containing billions of peptides, and various purported generic versions of the drug.
Latest:
The Application of Computational Chemistry to Problems in Mass SpectrometryWith computational chemistry, chemists can now study chemical phenomena by performing computationally intense calculations on computers rather than examining reactions and compounds experimentally. This is especially attractive when the laboratory experiments are time consuming, costly, dangerous, or difficult. Modern computational chemistry tools are capable of determining molecular structures, molecular spectra, and energetics, and of elucidating reaction pathways and chemical reaction products.
Latest:
Testing the Limits of Ion Mobility Mass Spectrometry to Compare a Nonbiological Complex Drug Product and Purported Generics—A Case Study with CopaxoneThe analysis of oil samples containing many thousands of constituents best illustrates the benefits of ion mobility MS for complex samples. Here, we test the limits of ion mobility MS to discern differences between batches of Copaxone, a highly complex drug containing billions of peptides, and various purported generic versions of the drug.
Latest:
Testing the Limits of Ion Mobility Mass Spectrometry to Compare a Nonbiological Complex Drug Product and Purported Generics—A Case Study with CopaxoneThe analysis of oil samples containing many thousands of constituents best illustrates the benefits of ion mobility MS for complex samples. Here, we test the limits of ion mobility MS to discern differences between batches of Copaxone, a highly complex drug containing billions of peptides, and various purported generic versions of the drug.
Latest:
Testing the Limits of Ion Mobility Mass Spectrometry to Compare a Nonbiological Complex Drug Product and Purported Generics—A Case Study with CopaxoneThe analysis of oil samples containing many thousands of constituents best illustrates the benefits of ion mobility MS for complex samples. Here, we test the limits of ion mobility MS to discern differences between batches of Copaxone, a highly complex drug containing billions of peptides, and various purported generic versions of the drug.
Latest:
HPLC 2017 Topic Preview: Affinity Capillary Electrophoresis–A Powerful Tool to Investigate Biomolecular InteractionsThis is the final instalment of a series of articles exploring current topics in separation science that will be addressed at the HPLC 2017 conference in Prague, Czech Republic, from 18–22 June.
Latest:
Basic Principles for Purification Using Supercritical Fluid ChromatographyAlthough supercritical fluid chromatography (SFC) is not a new technique, preparative SFC is becoming increasingly more popular with advances in instrumentation, software and chemistry.
Latest:
High-Throughput Quantitative Analysis of Vitamin D Using a Multiple Parallel LC–MS System Combined with Integrated On-Line SPEA newly developed high-throughput method for the quantitation of vitamin D using both multiplexed LC and on-line SPE is discussed.
Latest:
Establishing USP Rebaudioside A and Stevioside Reference Standards for the Food Chemicals CodexHere's how these new reference standards were characterized.
Latest:
Applicability of Hydrogen–Deuterium Exchange in Comparing Conformations of Innovator to Biosimilar Biopharmaceutical ProductsSignificant recent advances now enable routine usage of HDX-MS for comparing the conformations of biopharmaceutical products.
Latest:
HPLC 2017 Topic Preview: Advances in Glycomics in Biology and MedicineThis is the fifth article in a series exploring current topics in separation science that will be addressed at the HPLC 2017 conference in Prague, Czech Republic, from 18–22 June.
Latest:
HPLC 2017 Topic Preview: The Role of LC–MS in LipidomicsThis is the sixth instalment of a series of articles exploring current topics in separation science that will be addressed at the HPLC 2017 conference in Prague, Czech Republic, from 18–22 June.
Latest:
Micro-Pillar Array Column Separations for Proteomics of Liver OrganoidsA micro-pillar array format for mapping the proteome of human stem cell-derived liver organoids using timsTOF–MS is presented.
Latest:
On the Surprising Retention Order of Ketamine Analogs Using a Biphenyl Stationary PhaseAn unexpected retention order for ketamine analogs was observed when using a biphenyl stationary phase for liquid chromatography-mass spectrometry (LC–MS).
Latest:
Enantiomeric Separation of Privileged Scaffold Derivatives in Early Drug Discovery Using Chiral SFCSuccessful therapeutic intervention often requires chiral medicines because of the intrinsic chirality of protein drug targets, which consist of L-amino acids. Potency, efficacy, and safety can be highly dependent on the precise stereochemical geometry of the molecules. Determining the biological profile of individual enantiomers in the early stages of drug discovery is important for successful optimization towards clinical candidates. Here we demonstrate the benefits of supercritical fluid chromatography (SFC) with three chiral stationary phases exemplified by high frequency resolution of 41 out of 50 chiral derivatives of eight commonly used drug discovery scaffolds including 1,3-thiazoles, 1,3-benzothiazoles, pyranoquinolones, indoles, and leucolines.
