Application Notes

The single-stranded DNA (ssDNA) content of AAV capsids in AAV-based gene therapy preparations impacts the efficacy of this treatment modality. We demonstrate that AAV8 capsids without and with full length ssDNA can be separated and their relative abundances determined on a Waters Protein-Pak Hi Res Q strong anion-exchange column.

Dow scientists improved their method-development workflow by upgrading their hardware and using specialized software.

Reveal More in your Food. Using QSight LC–MS/MS to get a fast, selective, and sensitive multi-residue method for the determination of 136 pesticides in Pepper.

In this study we demonstrate the benefits of the Thermo Scientific™ Orbitrap Exploris™ 240 LC-MS/MS for intact biopharmaceutical analysis under native conditions.

In this study, we demonstrate routine characterization of biotherapeutics through LC–MS peptide mapping using the Thermo Scientific™ Orbitrap Exploris™ 240 LC–MS/MS.

Retention-time prediction (RT) could hasten the identification of unknowns. See how scientists use prediction software to estimate the RT of environmental contaminants.

DAICEL’s CHIRALPAK® sub-2 µm columns yield sub 30-second chiral separations of Thalidomide and Naproxen under SFC conditions.

This application note provides quantitative analysis of δ9-THC from cannabidiol oil using a pyroprobe interfaced to a GC–MS.

This note looks at the analysis of N-nitrosamines in rubber teats, soothers, and toys, with specific focus on babies and young children under UK method BS EN 71-12:2016.

Reveal more in your food. Using QSight LC–MS/MS to get a fast, selective, and sensitive multi-residue method for the determination of 136 pesticides in pepper.

Isocratic HPLC method for the analysis of mycotoxins and aflatoxins uses the DFL-10 filter fluorescence detector with a photochemical reactor to improve sensitivity.

-Why ultrafiltration is important in chromatography -Applications for ultrafiltration -Using Vivaspins® for sample clarification

Method development for simultaneous analysis of ultrashort-chain, alternative, and legacy per- and polyfluoroalkyl substances (PFAS).

Method Development for Simultaneous Analysis of Ultrashort-Chain, Alternative, and Legacy per- and polyfluoroalkyl substances (PFAS).

• Improving disk extraction for Method 625.1 • Successful disk extraction for Method 8270E • Advantages of disk extraction for Method 1664B Oil & Grease

An AI treatment based on neural algorithms can now solve non-linear and unpredictable random variations of retention times inherent in chromatography technology.

Click the title above to open LCGC Europe Supplement May 2020, Volume 33, Number s5, in an interactive PDF format.

This application approaches how to achieve better resolution by evaluating and optimizing the gradient program when using a bioZen WidePore C4 LC column.

bioZen WidePore C4 is built upon core-shell technology with bioinert hardware to offer optimal particle and pore-size morphology for high reproducibility and resolution.

To overcome peak broadening, this application adjusts the column temperature for the bioZen WidePore C4 to improve peak shape for large molecules

This application analyzes how to reduce peak widths by adjusting the flow rate for intact and reduced NIST mAb when using a bioZen WidePore C4 LC column.

In this application, temperature, gradient program, and flow rates are explored and optimized for intact mass applications for mAbs when using bioZen WidePore C4.

PharmaFluidics’ μPAC™ capLC is evaluated for different user needs ranging from 12 samples per day in comprehensive mode to 65 samples per day in throughput mode.