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Easy-to-Use, Software-Driven, Positive Pressure Manifold
This work encapsulates the reliability that this new, seamless technology, Otto SPEcialist Positive Pressure Manifold, provides during a method of solid-phase extraction.
LC–MS Bioanalytical Quantification of Itaconic Acid
This application note highlights the automated sample preparation and extraction of itaconic acid from human plasma with subsequent LC–MS/MS analysis and quantification.
Real-Time Process Analytics and Control for Vaccine Nanoparticles and Macromolecules
eBook: Characterizing Vaccines with the Light Scattering Toolkit
White Paper: SEC-MALS for Absolute Biophysical Characterization
Analysis of Polymers in Organic Solvents by FFF-MALS
Application Note: Hyaluronic Acid MW and Conformation by SEC-MALS-IV
Application Note: Conformational Properties of Hyperbranched Hetero-polysaccharides by SEC-MALS-IV
LC–MS Nitrosamine Impurity Quantification
Simultaneous Analysis of 19 Novel Synthetic Cannabinoids in Urine
This application note outlines a solid-phase extraction (SPE) and LC–MS/MS method for the analysis of 19 synthetic cannabinoids in urine.
Protein and Peptide Identification for the bioZen™ Nano 2.6 μm XB-C18 LC Column in HeLa Lysate
In this technical note we show peptides and proteins identification using the bioZen nano XB-C18 column in either direct inject or trap and elute mode.
Improved Peptide Identification in HeLa Cell Lysates Using Core-Shell Technology
Sub-2 μm fully porous particles and core-shell particles in nano LC–MS were evaluated by separation performance and protein and peptide identifications in proteomics.
Investigating the Influence of Selectivity in Bottom-Up Proteomics
The effect of column selectivity, its importance in quality of data achieved in protein and peptide identifications in bottom-up proteomics applications, is demonstrated.
bioZen Nano LC Application Guide
bioZen Nano 75 µm LC columns offer two advanced particle platforms, three unique column chemistries, and SecurityLINK Fitting Technology for a zero-dead volume connection.
Determining Trap Loadability Using the bioZen™ 3 μm Polar C18 Nano Column in Conjunction with the bioZen RP1 Nano Trap Column
In this application note we explore the effects of trap loadability using a bioZen 3 μm Polar C18 nano column in conjunction with the bioZen RP1 (C18) nano trap column.
Coupling Minaturized SPE with bioZen XB-C18 Nano Core-Shell Technology for the Detection of SARS-CoV-2 Nucelocapsid Protein Viral Peptides in Nasopharyngeal Samples
In this technical note we provide a miniaturized LC–MS and SPE method for the reliable and accurate detection of viral pesticides.
Investigating the Performance Attributes of Stationary-Phase Selectivity and Particle Morphology in Nano LC–MS
Multiple selectivity options in nano LC columns allows users to tailor the chromatography for the compounds of interest to the researcher.
Deep Proteome Coverage on HeLa Lysate Using a bioZen™ Fractionation Column for High pH (Basic Reversed-Phase) Fractionation in Combination with a bioZen Nano Peptide XB-C18 Column for Nano Flow LC–MS
We demonstrate how to achieve deep proteome coverage on HeLa cell lysate using a high pH reversed-phase fractionation strategy in combination with nano flow LC–MS.
bioZen High pH Fractionation Application Guide
The bioZen high pH fractionation HPLC column provides superior performance using titanium hardware, minimizing nonspecific adsorption for peptide identifications.
Increasing Sensitivity by Scaling Down from Micro- to Nano-Flow LC
In this technical note we explore column miniaturization effects attained by reducing column ID from 300 μm to 75 μm and its effects on sensitivity.
Column Reproducibility and Robustness Using the bioZen Nano 2.6 μm XB-C18 LC Column
In this application we show reproducible results across multiple columns as well as the robust ability of the bioZen 2.6 μm XB-C18 column after 100 injections.
Application Note: Native Online HIC–MS Analysis of mAbs
Charge variants of 28 mAbs were analyzed under MS-compatible conditions using YMC’s BioPro IEX SF column. Each mAb of different pI was separated from its variants
Charge Variant Analysis of 28 mAbs
Leuprorelin Analysis Using YMC-Triart Bio C18
In reference to the Japanese Pharmacopeia, YMC-Triart Bio C18 was used to analyze the peptide leuprorelin (GnRH analogue) and separate it from its degradation products.
Analysis of Bevacizumab by SEC–MALLS
In this application note, YMC’s dedicated SEC column for antibodies, YMC-SEC MAB, has been used to develop a method for bevacizumab using MALLS detection.
Application Note: Native Online SCX-MS Analysis of mAbs
LC–HRMS Analysis of the ASO Mipomersen
Mipomersen was analyzed by LC–HRMS using a biocompatible YMC-Triart C8 metal-free column ensuring symmetric peaks, high sensitivity, and no carryover effects.
SEC Separation of ADC Brentuximab Vedotin
The antibody-drug conjugate was separated from its aggregates and fragments in only one run using a YMC-SEC MAB column and varying mobile phases.
Application Note: Native Online HIC–MS of Cys-linked ADCs
In this application note, the DAR of the SigmaMAb ADC-mimic was determined using YMC’s BioPro HIC BF column and a nanospray ionization mass spectrometer.
PTR-TOF Mobile Air Quality Monitoring
IONICON real-time VOC analyzers are frequently deployed in mobile laboratories, contributing to public safety, tracking air pollution where and when it matters.