Application Notes

This application note demonstrates how accelerated solvent extraction (ASE) can extract a variety of PFAS from soil.

This application note demonstrates dual eluent generation cartridge performance for profiling galactosyl-oligosaccharides using HPAE-PAD.

Thermo Scientific Dionex CarboPac PA300-4µm column allows simplified, high-resolution sorbitol separation and quantification in complex samples.

This work describes a simple and fast method for the analysis of sixteen commonly analyzed cannabinoids utilizing a PerkinElmer LC 300 HPLC with PDA detector.

This application note demonstrates how Norma Oficial Mexicana for agave syrup carbohydrate analysis is executed with a Thermo Scientific Dionex CarboPac PA1-1 mm column using HPAE-PAD in EGC mode.

Nitrosamines are potentially dangerous genotoxic compounds that have been recently found within some pharmaceutical products. We demonstrate highly sensitive methods to accurately detect and quantify these compounds.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC–MS/MS for measuring pesticides in spinach purchased from local grocers is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in honey purchased from local apiaries is described in this application note.

The efficacy of the JMS-TQ4000GC triple-quadrupole GC-MS/MS for measuring pesticides in kale purchased from local grocers is described in this application note.

Combining high-resolution size exclusion chromatography columns with highly sensitive MALS detection characterizes oligonucleotides and structurally-related impurities.

This technical note explores a new trityl-on procedure that minimizes the risk of depurination.

This application note presents a case study for metabolite profiling of model pharmaceutical compounds using HRAM MS and small molecule ID software for data processing.

Extraction of oligo therapeutics from biological samples for LC–MS bioanalysis

Using the Clarity OTX extraction protocol vendor recommendations, we have demonstrated its use to develop a method for the extraction of therapeutic oligos from plasma.

Method development for simultaneous analysis of ultrashort-chain, alternative, and legacy per- and polyfluoroalkyl substances (PFAS).

Historically, helium has been used as a makeup or carrier gas. Learn about the disadvantages of helium and why so many laboratories are switching to nitrogen gas for GC.

This technical note discusses 2' cleavage and RNA sample preparation prior to trityl-on Clarity QSP cartridge or high-throughput purification.

As synthetic oligonucleotide therapeutics traverse the drug-development path, there is an increasing need for TK and PK/PD studies in drug discovery and development.

Common frequently asked question for oligonucleotides. This includes questions about characterization to purification and from sample preparation to LC separation.

This technical note discusses a simple, yet quick and effective solution for isolating and analyzing therapeutic oligonucleotides using Clarity OTX, an extraction kit.

Advance your oligonucleotide work, from sample preparation to analysis and purification

To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used.

In EPA 524.4, nitrogen replaced helium in purging VOCs from drinking water samples. CDS 7000 concentrator with a 7450 autosampler meets and exceeds the requirements.

This eBook covers the most common EPA regulations and methods analytical laboratories employ to meet the challenges of VOC analysis for environmental samples.

Clarity QSP provides an alternative trityl-on approach for separating truncated sequences and synthetic contaminants from the protected full-length sequence.

This guide for routine beverage analysis demonstrates essential testing with one analyzer. Learn more about fast turnaround, reduced human error, and reduced reagent use.

This application note demonstrates the quantitative analysis of microplastics using direct thermal desorption (TD) combined GC–MS.