Application Notes

Clarity QSP provides an alternative trityl-on approach for separating truncated sequences and synthetic contaminants from the protected full-length sequence. By incorporating a polymeric sorbent with a unique buffer formula, aborted fragments and synthetic contaminants are removed during sample loading offering a departure from the traditional RPC mechanism. Multiple buffers and gradient elutions are eliminated, thereby making Clarity QSP a 3-step product for trityl-on oligonucleotide purification.

As synthetic oligonucleotide therapeutics move through the drug-development path, the need for TK and PK/PD studies in drug discovery and development has increased.

Simple, quick, effective solution for isolating and analyzing therapeutic oligonucleotides using Clarity OTX, an extraction kit based on mixed-mode ion-exchange SPE.

To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used.

Trityl-on methodologies for the analysis of crude synthetic oligonucleotides has many benefits however depurination during trityl-on methodologies can lead to nucleic acid damage. This technical note explores a new trityl-on procedure that minimizes the risk of depurination.

Extraction of Oligo therapeutics from biological samples for LC/MS bioanalysis.

Fortis Technologies has launched a new application note on the analysis of cannabinoids. A sample of twelve cannabinoids was analyzed by LC–MS in 7 minutes.  

Learn how to convert your GC carrier gas from helium to hydrogen with this step-by-step guide to avoid the increasing cost of helium.

GCxGC TOFMS analysis can be overwhelming, but ChromaTOF Tile can quickly compare these data sets to bring statistically significant differences to the forefront.

A fast separation of remdesivir and its active metabolite GS-441524 for the treatment of COVID-19 is obtained in only 3 minutes using a YMC-Triart C18 UHPLC column.

Estrone, beta-estradiol, and estriol were derivatized from plasma using Novum PRO 96-Well Plates SLE to provide less background noise.

In this application, serum was cleaned up and compared with both a single protein precipitation protocol and also by the addition of a phospholipid removal product.

Miniaturized LC–MS and SPE method for the reliable and accurate detection of viral pesticides at 1 fmol/uL using SARS-CoV-2 nucleocapsid protein as a model system.

A quantitative LC–MS/MS method using a room-temperature hydrolysis with an advanced SPE product for the analysis of designer and pharmaceutical benzodiazepines in urine