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Extraction and LC/MS Analysis of Oligonucleotide Therapeutics from Biological Matrices Using Clarity® OTX™ SPE and Clarity Oligo-MS™ HPLC/UHPLC Columns
This technical note discusses a simple, yet quick and effective solution for isolating and analyzing therapeutic oligonucleotides using Clarity OTX, an extraction kit.
Clarity Biosolutions for Synthetic DNA/RNA Guide
Advance your oligonucleotide work, from sample preparation to analysis and purification
Extraction of 2’-MOE Phosphorothioate from Tissue Using Clarity OTX Solid Phase Extraction (SPE)
To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used.
Analysis of VOCs Using EPA 524.4
In EPA 524.4, nitrogen replaced helium in purging VOCs from drinking water samples. CDS 7000 concentrator with a 7450 autosampler meets and exceeds the requirements.
Analysis of VOCs in Environmental Samples
This eBook covers the most common EPA regulations and methods analytical laboratories employ to meet the challenges of VOC analysis for environmental samples.
Comparing Performance of High-Throughput, Trityl-on RNA/DNA Purification Products
Clarity QSP provides an alternative trityl-on approach for separating truncated sequences and synthetic contaminants from the protected full-length sequence.
Analytical guide for routine beverage analysis
This guide for routine beverage analysis demonstrates essential testing with one analyzer. Learn more about fast turnaround, reduced human error, and reduced reagent use.
Addressing the challenges of microplastic characterisations
This application note demonstrates the quantitative analysis of microplastics using direct thermal desorption (TD) combined GC–MS.
Beer Quality Control: Tips and Tricks for Your Microbiology/Analytical Lab
Running a Commercial ISO 17025 POPs Lab During a Pandemic
Increasing Sensitivity by Scaling Down from Micro to Nano Flow LC
In this technical note we explore column miniaturization effects attained by reducing column ID from 300 μm to 75 μm and its effects on sensitivity.
Improved Peptide Identifications in HeLa Cell Lysates Using Core-Shell Technology
Impact of sub-2 μm fully porous particles and core-shell particles in nano LC–MS evaluated by separation performance and protein and peptide identifications in proteomics.
Deep Proteome Coverage on HeLa Lysate using a bioZen™ Fractionation Column for High pH (Basic Reversed Phase) Fractionation in Combination with a bioZen Nano Peptide XB-C18 Column for Nano Flow LC–MS
How to achieve deep proteome coverage on HeLa cell lysate using a high pH reversed phase fractionation strategy in combination with nano flow LC–MS
Determining Trap Loadability using the bioZen™ 3 μm Polar C18 Nano Column in Conjunction with the bioZen RP1 Nano Trap Column
In this application note we explore the effects of trap loadability using a bioZen 3 μm Polar C18 nano column in conjunction with the bioZen RP1 (C18) nano trap column.
Protein and Peptide Identifications for the bioZen™ Nano 2.6 μm XB-C18 LC Column in HeLa Lysate
In this technical note we show peptides and proteins identified using the bioZen nano XB-C18 column in either direct inject or trap and elute mode.
Investigating the Influence of Selectivity in Bottom Up Proteomics
The effect of column selectivity and its importance in the quality of data achieved in protein and peptide identifications in bottom-up proteomics applications is demonstrated.
Column Reproducibility and Robustness using the bioZen Nano 2.6 μm XB-C18 LC Column
In this application, we show reproducible results across multiple columns as well as the robust ability of the bioZen 2.6 μm XB-C18 column after 100 injections.
Coupling Miniaturized SPE with bioZen XB-C18 Nano Core-Shell Technology for the Detection of Sas-CoV-2 Nucelocapsid Protein Viral Peptides in Nasopharyngeal Samples
A miniaturized LC–MS and SPE method for the reliable and accurate detection of viral pesticides at 1 fmol/uL using SARS-CoV-2 nucleocapsid protein as a model system.
A New Rapid, Simple and Efficient Extraction Method for PFAS from Soils
Data Integrity: Solutions for Regulatory Compliance within a Pharma QC Environment
Solutions for Environmental Testing
Microwave Extraction of Semi-Volatile Organic Compounds from Soil
Environmental Extractions - Comparison of US EPA 3545A and 3546 Methods
The Extraction of PFAS Molecules from Spiked Soils
Automated Extraction of Semi-Volatile Organic Compounds from Soil
Hexavalent Chromium Determination Hamilton PRP-X100 Anion Exchange HPLC Column v2
Arsenic Speciation on Hamilton PRP-X100 v2
Separation of Halo Acetic Acids by Ion Exclusion
Flexible Anion Analysis with Hamilton PRP-X100 and X110 Columns v2
Separation of Aflatoxins on HxSil C18 v2