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Discovery of Biomarkers in Breath (Sept 2022)
This study describes the development of an analytical platform based upon TD–GC×GC–TOF-MS and shows its application to the collection and analysis of breath samples.
Analysis of 26 Natural and Synthetic Opioids in Blood and Urine Using Clean Screen® DAU SPE and Selectra® DA UHPLC Column
Pathogen-Specific Biomarkers in Bacterial Pneumonia
Characterization of pathogen-specific biomarkers in bacterial pneumonia using high-capacity sorptive extraction, thermal desorption–GC–MS, and automated chemometrics
Monitoring Disinfection By-Products in Water
Nontarget screening of organic pollutants in water using thin-film SPME, GC×GC, and TOF-MS to determine compositional differences in water purification treatment
Development of Mass Spectrometry Search Algorithm for Mixed Microplastics by Py–GC/MS
Selection of UHPLC Columns for Nucleic Acid Oligomer Analysis (Sept 2022)
Characterizing Branched Polymers by Light Scattering
SEC with multi-angle light scattering (SEC-MALS) or in conjunction with a viscometer (SEC-MALS-IV) effectively characterizes branching in polymers.
Exosome Characterization in Biological Matrices Using AF4-NTA
FFF combined with NTA can be used in the development of therapeutics for biological samples for the optimization process in clinical trials under in vivo conditions.
SEC–MALS Method for Characterizing mRNA (Sept 2022)
SEC–MALS quantifies biophysical attributes of mRNA, including molar mass, percent aggregates, Rg, and Rh, and how they are affected by formulation and storage conditions.
Characterizing AAVs with Light Scattering
Wyatt’s instruments and techniques constitute platform methods for effective product and process development, as well as quality control of AAVs for gene therapy.
Light Scattering Toolkit for Vaccines
Light scattering facilitates vaccine development by enabling the analysis of size, shape, molar mass, and other parameters derived from these properties.
Characterizing AAVs with SEC-MALS
SEC-MALS is a platform method for effective product and process development, as well as quality control, of AAVs for gene therapy.
Quantifying Protein PEGylation Processes
SEC–MALS characterizes PEGylated proteins to determine the protein-PEG ratio and the molar masses of the constituent protein and PEG at each eluting fraction.
Understanding Antibody and Viral Glycoprotein Interactions (Sept 2022)
SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP: antibody interactions.
Characterizing Lentiviral and Gammaretroviral Vectors
This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retroviral viral vectors.
Lipid Nanoparticle and Liposome Quantification
Field-flow fractionation with multi-angle and dynamic light scattering (FFF–MALS–DLS) combines size-based separation with absolute size and structure determination.
LNP Characterization in Product Development
Light scattering quantifies key attributes of lipid nanoparticle gene vectors such as payload, size, titer, and stability in formulation and physiological media.
Biologically Active Increasing Length Peptides
This brief communication highlights the assessment of Hamilton PRP-3 HPLC column attributes when analyzing biologically active peptides.
High-Throughput Automated Workflow for Mineral Oil Determination in Water
Cost-saving benefits are achieved through an automated workflow for mineral oil analysis in water by in-vial liquid-liquid extraction, clean-up, and on-line GC analysis
Determination of Mycotoxins in Food (Sept 2022)
Multiclass-multianalyte method for mycotoxin testing in foods using immunoaffinity column sample clean-up with QSight LC–MS/MS
The Chiral Resolution of Fluoxetine (Sept 2022)
This application note is the first reported separation of Fluoxetine on polysaccharide-based chiral HPLC columns, and it comes on Daicel’s newest column, CHIRALPAK® IK.
Pharma 4.0 and the Digital Regulated Laboratory Part 2: Digital Laboratory Automation Strategy and Process Mapping
Pyrolysis-GC–MS Software for Microplastics Analysis
This application note demonstrates pyrolysis–gas chromatography/mass spectrometry libraries for identification and quantification of microplastics.
Biomarker Analysis for the Clustering of Benignant Nevi from Melanomas
This application note demonstrates how an affordable benchtop MALDI-TOF MS can be used to screen for liquid biomarkers for the diagnosis of melanoma.
Quality Control Analysis of Synthetic Peptides
A complete solution for the high-throughput, automated QC analysis of synthetic products using an affordable benchtop MALDI-TOF mass spectrometer and QC Reporter software.
Negative Mode MALDI-TOF Analysis of Synthetic Oligonucleotides
This application shows an example of MALDI-TOF analysis for genotyping, using cystic fibrosis disease, and demonstrates the benefits of negative ion mode.
Confirmation of Synthesis of Organic Functional Materials
This application note showcases the ability of an affordable benchtop MALDI-TOF MS to efficiently measure various types of organic functional materials.
N-Glycan Analysis of ACE2 as SARS-CoV-2 Receptor
This article shows that the N-glycans of ACE2, a receptor of SARSCoV-2, and their sialic acid linkage types can be easily evaluated using MALDI-TOF analysis.
Extra-virgin Olive Oil Authentication Using MALDI-TOF MS
This application highlights a robust analytical method to pinpoint a common fraud affecting the olive oil industry: extra virgin olive oil adulteration with cheaper vegetable oils.
Characterization of a PEG Conjugated Medicine
We present a solution for the characterization of a vitamin E-TPGS polymer sample using a benchtop linear MALDI-TOF MS with Polymerix polymer data analysis software.