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Light Scattering Toolkit for Vaccines
Light scattering facilitates vaccine development by enabling the analysis of size, shape, molar mass, and other parameters derived from these properties.
Characterizing AAVs with SEC-MALS
SEC-MALS is a platform method for effective product and process development, as well as quality control, of AAVs for gene therapy.
Quantifying Protein PEGylation Processes
SEC–MALS characterizes PEGylated proteins to determine the protein-PEG ratio and the molar masses of the constituent protein and PEG at each eluting fraction.
Understanding Antibody and Viral Glycoprotein Interactions (Sept 2022)
SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP: antibody interactions.
Characterizing Lentiviral and Gammaretroviral Vectors
This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retroviral viral vectors.
Lipid Nanoparticle and Liposome Quantification
Field-flow fractionation with multi-angle and dynamic light scattering (FFF–MALS–DLS) combines size-based separation with absolute size and structure determination.
LNP Characterization in Product Development
Light scattering quantifies key attributes of lipid nanoparticle gene vectors such as payload, size, titer, and stability in formulation and physiological media.
Biologically Active Increasing Length Peptides
This brief communication highlights the assessment of Hamilton PRP-3 HPLC column attributes when analyzing biologically active peptides.
High-Throughput Automated Workflow for Mineral Oil Determination in Water
Cost-saving benefits are achieved through an automated workflow for mineral oil analysis in water by in-vial liquid-liquid extraction, clean-up, and on-line GC analysis
Determination of Mycotoxins in Food (Sept 2022)
Multiclass-multianalyte method for mycotoxin testing in foods using immunoaffinity column sample clean-up with QSight LC–MS/MS
The Chiral Resolution of Fluoxetine (Sept 2022)
This application note is the first reported separation of Fluoxetine on polysaccharide-based chiral HPLC columns, and it comes on Daicel’s newest column, CHIRALPAK® IK.
Pharma 4.0 and the Digital Regulated Laboratory Part 2: Digital Laboratory Automation Strategy and Process Mapping
Pyrolysis-GC–MS Software for Microplastics Analysis
This application note demonstrates pyrolysis–gas chromatography/mass spectrometry libraries for identification and quantification of microplastics.
Biomarker Analysis for the Clustering of Benignant Nevi from Melanomas
This application note demonstrates how an affordable benchtop MALDI-TOF MS can be used to screen for liquid biomarkers for the diagnosis of melanoma.
Quality Control Analysis of Synthetic Peptides
A complete solution for the high-throughput, automated QC analysis of synthetic products using an affordable benchtop MALDI-TOF mass spectrometer and QC Reporter software.
Negative Mode MALDI-TOF Analysis of Synthetic Oligonucleotides
This application shows an example of MALDI-TOF analysis for genotyping, using cystic fibrosis disease, and demonstrates the benefits of negative ion mode.
Confirmation of Synthesis of Organic Functional Materials
This application note showcases the ability of an affordable benchtop MALDI-TOF MS to efficiently measure various types of organic functional materials.
N-Glycan Analysis of ACE2 as SARS-CoV-2 Receptor
This article shows that the N-glycans of ACE2, a receptor of SARSCoV-2, and their sialic acid linkage types can be easily evaluated using MALDI-TOF analysis.
Extra-virgin Olive Oil Authentication Using MALDI-TOF MS
This application highlights a robust analytical method to pinpoint a common fraud affecting the olive oil industry: extra virgin olive oil adulteration with cheaper vegetable oils.
Characterization of a PEG Conjugated Medicine
We present a solution for the characterization of a vitamin E-TPGS polymer sample using a benchtop linear MALDI-TOF MS with Polymerix polymer data analysis software.
MALDI-TOF Detection of Sulfonated Azo Colorants in Sweets and Candies
Shown here, is a simple, fast way to obtain qualitative information on the azo colorant content of confectionery products for their safe use in the food industry.
Introduction to Ion Chromatography Mass Spectrometry (IC-MS)
Learn how this powerful tool that can handle many challenging analytical tasks
Use of 2D-Liquid Chromatography in GMP Regulated Laboratories
Overcoming the Challenges of Liquid Chromatography Method Transfer: A CDMO Perspective
This case study demonstrates how method modernization is less difficult than the common perception, and good practices can be put in place to streamline the process.
Batch-to-Batch Comparison of Sub-2 µm Diol-Linked Size-Exclusion Columns (August 2022)
NIST mAb was analyzed using six different batches of 1.8 µm 200 Å dSEC-2 media packed with 150 mm length and 4.6 mm inner diameter columns.
Method Development for ADC Kadcyla by Size-Exclusion LC
Method development using standard phosphate containing buffers with different percentages of Isopropanol for aggregate analysis of an antibody-drug conjugate, Kadcyla.
What are Enzyme Assays Method Choices?
Learn more about enzyme assay, enzyme method, and choices. Are you seeking a better way to automate your enzyme analysis? This guide will help with your decision-making.
Heat and High pH Forced Degradation of Antibodies
The hydrophilic nature of the Biozen dSEC-2 stationary phase shows favorable aggregate profiles for forced degradation work under high salt conditions.
Improved Sensitivity and Recovery Using a Biozen dSEC-2 Column
Higher peak area for Biozen dSEC 2 column showing less adsorption occurring. Superior peak shape and recovery under USP mobile-phase conditions with Biozen dSEC 2 column.
Guard Column Lifetime and Capacity to Protect the Biozen dSEC-2 Column
Robustness of guard and attached analytical column evaluated for efficiency of trastuzumab biosimilar Kanjinti at suitable loading masses of bovine serum albumin.