Application Notes

This application note shows that a single column to be used for the analysis of a wide range of molecular sizes, from intact proteins and monoclonal antibodies to digested peptides.

Application of C18, 1.6 µm UHPLC columns in the analysis of insulin with strong and weak ion pairing agents to see how they increase the height of the insulin peak.

This application note introduces the usefulness of wide pore columns, targeting large macromolecules.

We have you covered. From sample receipt to regulatory reporting, with the most comprehensive chromatography and mass spectrometry instrumentation in the world.

This application note introduces application data obtained by using FlexFire SEC Columns that have adopted newly developed superior silica.

There are multiple factors that affect enzyme assay analysis. Download this guide to learn more about the importance of accurate enzyme assay analysis.

Shodex™ has successfully developed the LB-800 columns which are suitable with MALS detection. The columns are well suited to provide signal at low concentration with low molecular weight standards.

Shodex™ has SB-800 HQ series for the analysis of water-soluble molecules and for the determination of molecular weight distribution.

This technical article introduces an example of multi-faceted analysis and monitoring of an EV sample purification process using a SEC column, Shodex™ OHpak SB-806 HQ, with 3 different detectors.

When selecting a suitable analytical SEC column, not only the analytical range for the fractionation, but adsorption of the target compounds, which influences the quantification and yield, should also be considered.

mRNA coupled to EGFP (enhanced green fluorescent protein) is analyzed using a widepore YMC-Accura Triart Bio C4 RP column as well as a non-porous BioPro IEX QF column.

This application note explains how SEC coupled with MALS can be used for the determination of structural changes in polysaccharides.

This application note outlines an extraction method for four natural cannabinoids and two major metabolites of Δ9-THC in blood using Clean Screen® THC SPE column.

A robust analysis method for steroids was developed that can readily be implemented by clinical, forensic, or anti-doping laboratories.

This application note features a unique, simple, and robust solid-phase extraction method for cannabinoids in urine followed by analysis with LC–MS/MS.

This application note introduces a simple targeted extraction method for the analysis of nine nitazene compounds from urine and blood using the Clean Screen® DAU column.

Learn more in this infographic about selecting a water purification system that fits your needs for laboratory needs.

Explore how a systematic screening strategy allows chromatographers to rapidly identify ideal method conditions.

This white paper explores the theory behind solid-core particles and the advantages they offer for small molecule analysis.

This article discusses the impact and theory of column temperature and how it can be a powerful tool for fine-tuning a separation during method development.

An increased number of samples demands increased throughput. This article discusses ways to achieve high throughput analysis with LC–MS analysis methods.

In LC separations, the majority of analytes are ionizable, so controlling the state the analytes are in is critical. Discover how to harness pH for method development.

As more gene therapy applications make inroads into research and clinical practice, the development and safe manufacturing of the therapeutic products involved have demanded more from associated analytical technologies. One of the most widely used gene-therapy vectors is AAV, and key technologies for the characterization of AAVs include CE and LC-MS.

This application note introduces some new application data obtained by using FlexFire SEC that is adopted by newly developed silica gel.